Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 5  |  Issue : 3  |  Page : 169--172

Bronchodilatory effect of ethanolic extract of the leaves of Nyctanthes arbortristis


Ramadan B Sopi1, Muhammad Feroz Hayat Khan2 
1 Department of Pharmacy-Biology, University of Prishtina, Prishtina, Kosovo
2 Department of Biomedical Sciences, Centre for Biomedical Research, University of Dhaka, Bangladesh

Correspondence Address:
Muhammad Feroz Hayat Khan
Centre for Biomedical Research, University of Dhaka, Dhaka 1000
Bangladesh

Background: Nyctanthes arbortristis has been used in traditional medicine for the treatment of asthma and cough. Aim: In this study, bronchodilatory effect of ethanolic extract of the N. arbortristis was investigated under in vitro conditions. The concentration-response curve of the tracheal smooth muscle (TSM) to histamine was recorded in presence or absence of ethanolic extract and Nω-nitro-l-arginine methyl ester (L-NAME). Dose-response effect of ethanolic extract on pre-constricted tissues was investigated. The ethanolic extract inhibited the histamine-induced maximum contractile responses of TSM ( P < 0.001). Ethanolic extract also cause dose-dependent relaxation of TSM. These effects were reversed by L-NAME. Phytochemical analysis showed the presence of typical plant constituents. These results suggest the possible use of extract of the leaves of N. arbortristis as a bronchodilator in therapeutic treatment of asthma.


How to cite this article:
Sopi RB, Hayat Khan MF. Bronchodilatory effect of ethanolic extract of the leaves of Nyctanthes arbortristis.Phcog Res 2013;5:169-172


How to cite this URL:
Sopi RB, Hayat Khan MF. Bronchodilatory effect of ethanolic extract of the leaves of Nyctanthes arbortristis. Phcog Res [serial online] 2013 [cited 2021 Jun 25 ];5:169-172
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2013;volume=5;issue=3;spage=169;epage=172;aulast=Sopi;type=0