Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 5  |  Issue : 2  |  Page : 109--112

The triterpenoid fraction from Trichosanthes dioica root exhibits in vitro antileishmanial effect against Leishmania donovani promastigotes


Sanjib Bhattacharya1, Moulisha Biswas2, Pallab K Haldar3 
1 Division of Pharmacognosy, Bengal School of Technology (A College of Pharmacy), Hooghly, India
2 Bengal Institute of Pharmaceutical Sciences, Nadia, India
3 Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India

Correspondence Address:
Sanjib Bhattacharya
Pharmacognosy Division, Bengal School of Technology (A College of Pharmacy), Delhi Road, Sugandha, Hooghly, West Bengal
India

Background: Trichosanthes dioica Roxb. (Cucurbitaceae), called pointed gourd in English is a dioecious climber found wild throughout the plains of the Indian subcontinent and traditionally used in India for several medicinal purposes. Objective: The present study was aimed at the evaluation of in vitro antileishmanial effect of triterpenoid fraction from T. dioica root (CETD). Materials and Methods: The antileishmanial activity of CETD was evaluated against Leishmania donovani (strain MHOM/IN/83/AG83)) promastigotes by in vitro promastigote cell toxicity assay by using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide). Potassium antimonyl tartrate was used as reference. Results: Here, CETD markedly inhibited the growth of L. donovani promastigotes in vitro in a concentration dependent manner and demonstrated IC 50 value of 18.75 μg/ml. The reference drug potassium antimonyl tartrate exhibited IC 50 of 7.52 μg/ml. Conclusion: From the present study it can be inferred that the triterpenoid fraction of T. dioica root exhibited remarkable antileishmanial activity against Leishmania donovani promastigotes in vitro.


How to cite this article:
Bhattacharya S, Biswas M, Haldar PK. The triterpenoid fraction from Trichosanthes dioica root exhibits in vitro antileishmanial effect against Leishmania donovani promastigotes.Phcog Res 2013;5:109-112


How to cite this URL:
Bhattacharya S, Biswas M, Haldar PK. The triterpenoid fraction from Trichosanthes dioica root exhibits in vitro antileishmanial effect against Leishmania donovani promastigotes. Phcog Res [serial online] 2013 [cited 2021 Apr 14 ];5:109-112
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2013;volume=5;issue=2;spage=109;epage=112;aulast=Bhattacharya;type=0