Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 4  |  Issue : 4  |  Page : 203--207

Evaluation of the protective and ameliorative properties of Garcinia kola on histamine-induced bronchoconstriction in guinea pigs


Mina T Ibulubo1, Gerald I Eze1, Raymond I Ozolua2, Doroteo Baxter-Grillo1, Dickson O Uwaya2 
1 Department of Anatomy, School of Basic Medical Sciences, University of Benin, Benin City, Nigeria
2 Department of Pharmacology and Toxicology, School of Pharmacy, University of Benin, Benin City, Nigeria

Correspondence Address:
Raymond I Ozolua
Department of Pharmacology and Toxicology, University of Benin, Benin City-300001
Nigeria

Background: Garcinia kola is popularly used in African traditional medicine for the relief of acute bronchoconstrictive episodes. Objective: In this study, we examined the anti-asthmatic and morphological effects of the ethanol extract of G. kola in animal model. Materials and Methods: Guinea pigs were sensitized with ovalbumin and then given doses of 200 or 400 mg/kg/day for 21 consecutive days. Theophylline (10 mg/kg/day) was used as a standard. At the end of the exposure, the animals were exposed to 0.2% histamine aerosol in a chamber. Lymphocyte count, bronchial histology and morphometry were done. Results: Compared with non-sensitized controls, 200 mg/kg/day dose of the extract significantly (P < 0.05) increased the time taken for onset of preconvulsive dyspnea while the dose of 400 mg/kg/day significantly (P < 0.01) reduced bronchial wall thickness. Lymphocytes counts were not significantly affected but the bronchi of extract-treated animals were histologically clearer of lesions visible in the sensitized. Conclusion: These protective and ameliorative properties lend credence to the use of G. kola in ethnomedicine.


How to cite this article:
Ibulubo MT, Eze GI, Ozolua RI, Baxter-Grillo D, Uwaya DO. Evaluation of the protective and ameliorative properties of Garcinia kola on histamine-induced bronchoconstriction in guinea pigs.Phcog Res 2012;4:203-207


How to cite this URL:
Ibulubo MT, Eze GI, Ozolua RI, Baxter-Grillo D, Uwaya DO. Evaluation of the protective and ameliorative properties of Garcinia kola on histamine-induced bronchoconstriction in guinea pigs. Phcog Res [serial online] 2012 [cited 2020 Oct 26 ];4:203-207
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2012;volume=4;issue=4;spage=203;epage=207;aulast=Ibulubo;type=0