Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 4  |  Issue : 3  |  Page : 161--165

Chemical composition, antibacterial and antifungal activities of essential oil from Cordia verbenacea DC leaves


Fabiola F. G. Rodrigues1, Liana G. S. Oliveira1, Fábio F. G. Rodrigues1, Manuele E Saraiva1, Sheyla C. X. Almeida1, Mario E. S. Cabral1, Adriana R Campos2, Jose Galberto M Costa1 
1 Department of Biological Chemistry, Molecular Bioprospection Post-graduation Program, Laboratory of Natural Products Research, Regional University of Cariri, Crato, CE, Brazil
2 Vice-Rectory of Research and Post-Graduation, University of Fortaleza, Fortaleza, CE, Brazil

Correspondence Address:
Jose Galberto M Costa
Department of Biological Chemistry, Regional University of Cariri, Rua Cel. Antônio Luiz 1161, Pimenta - 63105-000, Crato-CE
Brazil

Background: Cordia verbenacea is a Brazilian coastal shrub popularly known as «DQ»erva baleeira«DQ». The essential oil from fresh leaves was obtained by hydrodistillation and analyzed by CG/MS. The main components were identified as β-caryophyllene (25.4%), bicyclogermacrene (11.3%), δ-cadinene (9.%) and α-pinene (9.5%). In this study, the antimicrobial activity of Cordia verbenacea was evaluated. Materials and Methods: The minimal inhibitory concentration (MIC) of the essential oil was obtained using the broth microdilution assay (from 512 to 8 μg/ml). Results: The results showed that the essential oil presented fungistatic activity against Candida albicans and Candida krusei and antibacterial activity against Gram-positive strains (Staphylococcus aureus and Bacillus cereus) and against multiresistant Gram-negative (Escherichia coli 27), in all tests the MIC was 64 μg/ml. When the essential oil was associated to aminoglycosides (subinhibitory concentrations, MIC/8), a synergic and antagonic activity was verified. The synergic effect was observed to the amikacin association (MIC reduction from 256 mlto 64 μg/ml) in all strains tested. Conclusion: The essential oil of Cordia verbenacea influences the activity of antibiotics and may be used as an adjuvant in antibiotic therapy against respiratory tract bacterial pathogens.


How to cite this article:
Rodrigues FF, Oliveira LG, Rodrigues FF, Saraiva ME, Almeida SC, Cabral ME, Campos AR, Costa JM. Chemical composition, antibacterial and antifungal activities of essential oil from Cordia verbenacea DC leaves.Phcog Res 2012;4:161-165


How to cite this URL:
Rodrigues FF, Oliveira LG, Rodrigues FF, Saraiva ME, Almeida SC, Cabral ME, Campos AR, Costa JM. Chemical composition, antibacterial and antifungal activities of essential oil from Cordia verbenacea DC leaves. Phcog Res [serial online] 2012 [cited 2021 Feb 25 ];4:161-165
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2012;volume=4;issue=3;spage=161;epage=165;aulast=Rodrigues;type=0