Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 3  |  Issue : 1  |  Page : 9--12

In vitro antiproliferative activity of Annona reticulata roots on human cancer cell lines


HM Suresh1, B Shivakumar2, K Hemalatha3, SS Heroor1, DS Hugar1, K.R.S Sambasiva Rao4 
1 Department of Pharmacognosy, H.K.E. Society's College of Pharmacy, Gulbarga, Karnataka, India
2 Department of Pharmaceutical Chemistry, B.L.D.E.A.'s College of Pharmacy, Bijapur, Karnataka, India
3 Department of Pharmaceutical Chemistry, Mallareddy College of Pharmaceutical Sciences, Hyderabad, India
4 Department of Biotechnology, Acharya Nagarjuna University, Guntur, AP, India

Correspondence Address:
H M Suresh
Department of Pharmacognosy, H.K.E. Society«SQ»s College of Pharmacy, Sedam Road, Gulbarga, Karnataka
India

Background: The phytochemical and pharmacological activities of Annona reticulata components suggest a wide range of clinical application in lieu of cancer chemotherapy. Materials and Methods: Ethanol and aqueous extracts of roots of Annona reticulata Linn were studied for their in vitro antiproliferative activity on A-549 (human lung carcinoma), K-562 (human chronic myelogenous leukemia bone marrow), HeLa (human cervix) and MDA-MB (human adenocarcinoma mammary gland) cancer cell lines by MTT [3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide] colorimetric assay. Results: The ethanol extract exhibited a prominent inhibitory effect against A-549, K-562, HeLa and MDA-MB human cancer cell lines at a concentration range between 10 and 40 μg/ml, whereas the aqueous extract showed a lower activity at the same concentration. Simultaneously, the effect of the ethanol extract toward the inhibition of Vero cell line proliferation was lower in comparison with the cancer cell lines. Conclusion: The significant antiproliferative activity of the ethanol extract of Annona reticulata roots against A-549, K-562, HeLa and MDA-MB human cancer cell lines may be attributed toward the collective presence of acetogenins, alkaloids and lower inhibitory effect on Vero cell line, which suggests Annona reticulata be used as a chemopreventive agent in cancer therapy.


How to cite this article:
Suresh H M, Shivakumar B, Hemalatha K, Heroor S S, Hugar D S, Sambasiva Rao K. In vitro antiproliferative activity of Annona reticulata roots on human cancer cell lines.Phcog Res 2011;3:9-12


How to cite this URL:
Suresh H M, Shivakumar B, Hemalatha K, Heroor S S, Hugar D S, Sambasiva Rao K. In vitro antiproliferative activity of Annona reticulata roots on human cancer cell lines. Phcog Res [serial online] 2011 [cited 2020 Oct 26 ];3:9-12
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2011;volume=3;issue=1;spage=9;epage=12;aulast=Suresh;type=0