Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 2  |  Issue : 3  |  Page : 181--185

The evaluation of antinociceptive activity of alkaloid, methanolic, and aqueous extracts of Malaysian Mitragyna speciosa Korth leaves in rats


Azadeh Sabetghadam, Surash Ramanathan, Sharif Mahsufi Mansor 
 Centre for Drug Research, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia

Correspondence Address:
Sharif Mahsufi Mansor
Centre for Drug Research, Universiti Sains Malaysia, 11800 Minden, Penang
Malaysia

Mitragyna speciosa Korth is a medicinal plant indigenous to Thailand and Malaysia and has been known for its narcotic and coca-like effects. Many studies have been performed on the antinociceptive effect of the plant extracts of Thai origin; however, limited studies have been reported till date on M. speciosa extracts of Malaysian origin. Various concentrations of alkaloid (5-20 mg/kg), methanolic (50-200 mg/kg), and aqueous (100-400 mg/kg) extracts of Malaysian M. speciosa leaves were prepared and orally administered to nine groups of rats. Morphine (5 mg/kg, s.c.) and aspirin (300 mg/kg, p.o.) were used as control. Antagonism of the antinociceptive activity was evaluated by pretreatment with naloxone at a dose of 2 mg/kg (i.p.). Results showed that oral administration of the alkaloid (20 mg/kg), methanolic (200 mg/kg), and aqueous (400 mg/kg) extracts significantly prolonged the latency of nociceptive response compared with control groups in both hot plate and tail flick tests (P < 0.05). Antinociceptive action of the alkaloid (20 mg/kg), methanolic (200 mg/kg), and aqueous (400 mg/kg) extracts was significantly blocked by naloxone. In conclusion, these results suggest the presence of antinociceptive effect in various extracts of Malaysian M. speciosa leaves. In addition, the antinociceptive effective doses vary depending on the type of solvents used for extraction.


How to cite this article:
Sabetghadam A, Ramanathan S, Mansor SM. The evaluation of antinociceptive activity of alkaloid, methanolic, and aqueous extracts of Malaysian Mitragyna speciosa Korth leaves in rats.Phcog Res 2010;2:181-185


How to cite this URL:
Sabetghadam A, Ramanathan S, Mansor SM. The evaluation of antinociceptive activity of alkaloid, methanolic, and aqueous extracts of Malaysian Mitragyna speciosa Korth leaves in rats. Phcog Res [serial online] 2010 [cited 2021 Feb 26 ];2:181-185
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2010;volume=2;issue=3;spage=181;epage=185;aulast=Sabetghadam;type=0