Hepatoprotective and Cytotoxic Activities of Abietic Acid from Isodon wightii (Bentham) H. Hara

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Abstract
Pharmacognosy Research,2016,8,3,206-208.
Published:May 2016
Type:Short Communication
Authors:
Author(s) affiliations:

Madhusudhanan Gogul Ramnath1, Ramaraj Thirugnanasampandan1, Sadasivam Mathusalini2, Palathurai Subramanium Mohan2

1Department of Biotechnology, Kongunadu Arts and Science College, Coimbatore, Tamil Nadu, INDIA.

2Department of Chemistry, Bharathiar University, Coimbatore, Tamil Nadu, INDIA.

Abstract:

Isodon (Lamiaceae) is a known source of bioactive terpenoids. Diterpenoids isolated from Isodon wightii (Bentham) H. Hara showed antibacterial, antiacetylcholinesterase, antioxidant, anticancer, and anticarcinogenic activities, etc., Hepatoprotective activity of ABA against lipopolysaccharide (LPS) induced liver injury in BALB/c mice was studied. Cytotoxic activity of ABA was tested against cervical cancer cells (HeLa) using MTT assay followed by propidium iodide (PI) staining to identify apoptosis. Histopathological analysis revealed that 1.5 μg/mL LPS induced liver damage was attenuated by ABA in a dose dependent manner. ABA showed cytotoxicity with IC50 value of 176.28 ± 0.02 μg/mL and PI staining of treated cells showed apoptosis. This study proves that ABA would be a promising natural compound for herbal drug preparation.

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Hepatoprotective and Cytotoxic Activities of Abietic Acid from Isodon wightii (Bentham) H. Hara

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