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1Biologically active compounds and pharmacological activities of species of the genus Crocus: A review
Olga Mykhailenko,Volodymyr Kovalyov,Olga Goryacha,Liudas Ivanauskas,Victoriya Georgiyants
Phytochemistry.2019;162()56
[DOI]
2Preventive effect of safranal against oxidative damage in aged male rat brain
Saeed SAMARGHANDIAN,Mohsen AZIMI-NEZHAD,Fariborz SAMINI
Experimental Animals.2015;64(1)65
[DOI]
3Phytochemical and anti-neuropathic investigations of Crocus sativus via alleviating inflammation, oxidative stress and pancreatic beta-cells regeneration
Karim Raafat,Maha Aboul-Ela,Abdalla El-Lakany
Chinese Herbal Medicines.2020;12(1)47
[DOI]
4Preparation and evaluation of anti-wrinkle cream containing saffron extract and avocado oil
Atefeh Naeimifar,Saman Ahmad Nasrollahi,Aniseh Samadi,Roya Talari,Seyed Sajad Ale-nabi,Amir Massoud Hossini,Alireza Firooz
Journal of Cosmetic Dermatology.2020;19(9)2366
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5The role of Safranal and saffron stigma extracts in oxidative stress, diseases and photoaging: A systematic review
Sanju Nanda,Kumud Madan
Heliyon.2021;7(2)e06117
[DOI]
6The role of Safranal and saffron stigma extracts in oxidative stress, diseases and photoaging: A systematic review
Ruqaya Jabeen,Mir Ajaz Akram,Muzafar Ahmad Sheikh
Heliyon.2020;7(2)263
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7Potential phytocompounds for developing breast cancer therapeutics: Nature’s healing touch
Javed Iqbal,Banzeer Ahsan Abbasi,Riffat Batool,Tariq Mahmood,Barkat Ali,Ali Talha Khalil,Sobia Kanwal,Sayed Afzal Shah,Riaz Ahmad
European Journal of Pharmacology.2018;827(2)125
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8Crocus sativus L. (saffron) for cancer chemoprevention: A mini review
Prasan R. Bhandari
Journal of Traditional and Complementary Medicine.2015;5(2)81
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9A comprehensive review of the pharmacological potential of Crocus sativus and its bioactive apocarotenoids
Syed Imran Bukhari,Mahreen Manzoor,M.K. Dhar
Biomedicine & Pharmacotherapy.2018;98(2)733
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10A comprehensive review of the pharmacological potential of Crocus sativus and its bioactive apocarotenoids
Azam Bolhassani
Biomedicine & Pharmacotherapy.2018;58(2)289
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11The effect of crocin on memory, hippocampal acetylcholine level, and apoptosis in a rat model of cerebral ischemia
Yu Yuan,Xiaosong Shan,Weidong Men,Hexin Zhai,Xiaoxia Qiao,Lianting Geng,Chunhui Li
Biomedicine & Pharmacotherapy.2020;130(2)110543
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12The effect of crocin on memory, hippocampal acetylcholine level, and apoptosis in a rat model of cerebral ischemia
Hifzur R. Siddique,Homa Fatma,Mohammad Afsar Khan
Biomedicine & Pharmacotherapy.2020;130(2)233
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13The effect of crocin on memory, hippocampal acetylcholine level, and apoptosis in a rat model of cerebral ischemia
Saeed Samarghandian,Tahereh Farkhondeh,Tayebeh Zeinali
Biomedicine & Pharmacotherapy.2020;130(2)193
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14The effect of crocin on memory, hippocampal acetylcholine level, and apoptosis in a rat model of cerebral ischemia
Saeed Samarghandian,Tahereh Farkhondeh
Biomedicine & Pharmacotherapy.2020;130(2)103
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15Main chemical compounds and pharmacological activities of stigmas and tepals of ‘red gold’; saffron
Tayebeh Shahi,Elham Assadpour,Seid Mahdi Jafari
Trends in Food Science & Technology.2016;58(2)69
[DOI]
16Synergistic Apoptotic Effect of Crocin and Paclitaxel or Crocin and Radiation on MCF-7 Cells, a Type of Breast Cancer Cell Line
Faeze Vali,Vahid Changizi,Majid Safa
International Journal of Breast Cancer.2015;2015(2)1
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17The impact of Crocus sativus stigma against methotrexate-induced liver toxicity in rats
Reyhane Hoshyar,Ahmadreza Sebzari,Mohadeseh Balforoush,Masoomeh Valavi,Mehran Hosseini
Journal of Complementary and Integrative Medicine.2019;17(2)1
[DOI]
18The impact of Crocus sativus stigma against methotrexate-induced liver toxicity in rats
Shahid Akbar
Journal of Complementary and Integrative Medicine.2020;17(2)725
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19An invivo study on the hepato-protective effects of Crocus sativus, Ziziphus jujuba and Berberis vulgaris against acute acetaminophen and rifampicin-induced hepatotoxicity
Maryam Moossavi,Reyhane Hoshyar,Mina Hemmati,Ali Farahi,Hossein Javdani
Clinical Phytoscience.2017;2(1)725
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20Safranal and its analogs inhibit Escherichia coli ATP synthase and cell growth
Mason Liu,Amon Amini,Zulfiqar Ahmad
International Journal of Biological Macromolecules.2017;95(1)145
[DOI]
21Saffron bioactives crocin, crocetin and safranal: effect on oxidative stress and mechanisms of action
Débora Cerdá-Bernad,Estefanía Valero-Cases,Joaquín-Julián Pastor,María José Frutos
Critical Reviews in Food Science and Nutrition.2020;95(1)1
[DOI]
22Saffron: An Old Medicinal Plant and a Potential Novel Functional Food
María José Bagur,Gonzalo Alonso Salinas,Antonia Jiménez-Monreal,Soukaina Chaouqi,Silvia Llorens,Magdalena Martínez-Tomé,Gonzalo Alonso
Molecules.2017;23(1)30
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23Functional Food and Cardiovascular Disease Prevention and Treatment: A Review
Sedigheh Asgary,Ali Rastqar,Mahtab Keshvari
Journal of the American College of Nutrition.2018;37(5)429
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24Functional Food and Cardiovascular Disease Prevention and Treatment: A Review
Abdul Bakrudeen Ali Ahmed,Rosna Mat Taha,Nordiyanah Anuar,Hashimah Elias,Sakinah Abdullah,Asif Khan,Asif Vijay Lobo,R. Vidhyavathi
Journal of the American College of Nutrition.2021;37(5)221
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25Molecular Mechanism of Crocin Induced Caspase Mediated MCF-7 Cell Death: In Vivo Toxicity Profiling and Ex Vivo Macrophage Activation
Hamid A Bakshi,Faruck Lukmanul Hakkim,Smitha Sam
Asian Pacific Journal of Cancer Prevention.2016;17(3)1499
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26Crocin attenuate Tumor Necrosis Factor-alpha (TNF-a) and interleukin-6 (IL-6) in streptozotocin-induced diabetic rat aorta
Saeed Samarghandian,Mohsen Azimi-Nezhad,Tahereh Farkhondeh
Cytokine.2016;88(3)20
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27The Natural Carotenoid Crocetin and the Synthetic Tellurium Compound AS101 Protect the Ovary against Cyclophosphamide by Modulating SIRT1 and Mitochondrial Markers
Giovanna Di Emidio,Giulia Rossi,Isabelle Bonomo,Gonzalo Luis Alonso,Roberta Sferra,Antonella Vetuschi,Paolo Giovanni Artini,Alessandro Provenzani,Stefano Falone,Gaspare Carta,Anna Maria D’Alessandro,Fernanda Amicarelli,Carla Tatone
Oxidative Medicine and Cellular Longevity.2017;2017(3)1
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28Evaluation of the Cytotoxic Activity of Crocin and Safranal, Constituents of Saffron, in Oral Squamous Cell Carcinoma (KB Cell Line)
Raheleh Jabini,Melika Ehtesham-Gharaee,Zohreh Dalirsani,Fatemeh Mosaffa,Zahra Delavarian,Javad Behravan
Nutrition and Cancer.2017;69(6)911
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29Prerequisite of a Holistic Blend of Traditional and Modern Approaches of Cancer Management
Mahima Kaushik,Swati Mahendru,Swati Chaudhary,Mohan Kumar,Shrikant Kukreti
Current Cancer Therapy Reviews.2019;15(1)56
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30Preventive Care for Gastrointestinal Disorders; Role of Herbal Medicines in Traditional Persian Medicine
Maryam Mosaffa Jahromi,Mehdi Pasalar,Suleiman Afsharypuor,Rasool Choopani,Mahmoud Mosaddegh,Mohammad Kamalinejad,Abdolali Mohagheghzadeh,Ali Mohammad Tamaddon,Kamran Bagheri Lankarani
Jundishapur Journal of Natural Pharmaceutical Products.2015;10(4)56
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31Isolation, purification and characterization of naturally derived Crocetin beta-d-glucosyl ester from Crocus sativus L. against breast cancer and its binding chemistry with ER-alpha/HDAC2
Mudasir A. Mir,Shabir Ahmad Ganai,Sheikh Mansoor,Sumira Jan,P. Mani,Khalid Z. Masoodi,Henna Amin,Muneeb U. Rehman,Parvaiz Ahmad
Saudi Journal of Biological Sciences.2020;27(3)975
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32Isolation, purification and characterization of naturally derived Crocetin beta-d-glucosyl ester from Crocus sativus L. against breast cancer and its binding chemistry with ER-alpha/HDAC2
Dezso Csupor,Barbara Tóth,Javad Mottaghipisheh,Andrea Zangara,Emad A.S. Al-Dujaili
Saudi Journal of Biological Sciences.2021;27(3)213
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33Mechanism behind the anti-tumour potential of saffron ( Crocus sativus L.): The molecular perspective
Sweta Patel,Maryam Sarwat,Tajdar H. Khan
Critical Reviews in Oncology/Hematology.2017;115(3)27
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34Mechanism behind the anti-tumour potential of saffron ( Crocus sativus L.): The molecular perspective
Jalil Tavakol-Afshari,Mohammad-Hossein Boskabady,Roshanak Salari
Critical Reviews in Oncology/Hematology.2020;115(3)485
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35Neuroprotective Potency of Saffron Against Neuropsychiatric Diseases, Neurodegenerative Diseases, and Other Brain Disorders: From Bench to Bedside
Yaqi Bian,Chen Zhao,Simon Ming-Yuen Lee
Frontiers in Pharmacology.2020;11(3)485
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36Bioactivity and Bioavailability of the Major Metabolites of Crocus sativus L. Flower
Simon Ming-Yuen Moratalla-López,Simon Ming-Yuen Bagur,Simon Ming-Yuen Lorenzo,Simon Ming-Yuen Salinas,Simon Ming-Yuen Alonso
Molecules.2019;24(15)2827
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37Discrimination of Different Parts of Saffron by Metabolomic-Based Ultra-Performance Liquid Chromatography Coupled with High-Definition Mass Spectrometry
Shuya Xu,Xiaojin Ge,Shimin Li,Xiaoyang Guo,Dandan Dai,Tiegang Yang
Chemistry & Biodiversity.2019;16(10)2827
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38Safranal induces DNA double-strand breakage and ER-stress-mediated cell death in hepatocellular carcinoma cells
Ala’a Al-Hrout,Amphun Chaiboonchoe,Basel Khraiwesh,Chandraprabha Murali,Badriya Baig,Raafat El-Awady,Hamadeh Tarazi,Amnah Alzahmi,David R. Nelson,Yaser E. Greish,Wafaa Ramadan,Kourosh Salehi-Ashtiani,Amr Amin
Scientific Reports.2018;8(1)2827
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39Safranal induces DNA double-strand breakage and ER-stress-mediated cell death in hepatocellular carcinoma cells
Martha B. Ramírez-Rosas,Adriana L. Perales-Torres,Rubén Santiago-Adame
Scientific Reports.2020;8(1)105
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40Effects of saffron ( Crocus sativus L.) supplementation on inflammatory biomarkers: A systematic review and meta-analysis
Omid Asbaghi,Mehdi Sadeghian,Omid Sadeghi,Somaye Rigi,Shing Cheng Tan,Azad Shokri,Seyed Mohammad Mousavi
Phytotherapy Research.2021;35(1)20
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41Saffron (Crocus sativus) pretreatment confers cardioprotection against ischemia-reperfusion injuries in isolated rabbit heart
Moni Nader,Nathalie Chahine,Charelle Salem,Ramez Chahine
Journal of Physiology and Biochemistry.2016;72(4)711
[DOI]
42Refractance-window as an innovative approach for the drying of saffron petals and stigma
Zahra Aghaei,Seid Mahdi Jafari,Danial Dehnad,Mohammad Ghorbani,Khodayar Hemmati
Journal of Food Process Engineering.2018;41(7)e12863
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43An updated review on therapeutic effects of nanoparticle-based formulations of saffron components (safranal, crocin, and crocetin)
Elaheh Mirhadi,Hooriyeh Nassirli,Bizhan Malaekeh-Nikouei
Journal of Pharmaceutical Investigation.2020;50(1)47
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44An Overview on Renoprotective Effects of Thymoquinone
Hanieh Shaterzadeh-Yazdi,Mohammad-Foad Noorbakhsh,Saeed Samarghandian,Tahereh Farkhondeh
Kidney Diseases.2018;4(2)74
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45Saffron Samples of Different Origin: An NMR Study of Microwave-Assisted Extracts
Anatoly Sobolev,Simone Carradori,Donatella Capitani,Silvia Vista,Agata Trella,Federico Marini,Luisa Mannina
Foods.2014;3(3)403
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46Nutritional and health beneficial properties of saffron (Crocus sativus L): a comprehensive review
Tareq Abu-Izneid,Abdur Rauf,Anees Ahmed Khalil,Ahmed Olatunde,Ahood Khalid,Fahad A. Alhumaydhi,Abdullah S. M. Aljohani,Md. Sahab Uddin,Mojtaba Heydari,Mars Khayrullin,Mohammad Ali Shariati,Adeyemi Oladapo Aremu,Ahmed Alafnan,Kannan R. R. Rengasamy
Critical Reviews in Food Science and Nutrition.2020;3(3)1
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47Anti-oxidative effects of safranal on immobilization-induced oxidative damage in rat brain
Saeed Samarghandian,Fariborz Samini,Mohsen Azimi-Nezhad,Tahereh Farkhondeh
Neuroscience Letters.2017;659(3)26
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48Saffron; An updated review on biological properties with special focus on cardiovascular effects
Samad Ghaffari,Neda Roshanravan
Biomedicine & Pharmacotherapy.2019;109(3)21
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49Saffron; An updated review on biological properties with special focus on cardiovascular effects
Deepu Pandita
Biomedicine & Pharmacotherapy.2021;109(3)325
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50Modification of a haematoxylin, eosin, and natural saffron staining method for the detection of connective tissue
Cassandra Ceccopieri,Joanna Skonieczna,Jan P. Madej
Journal of Veterinary Research.2021;0(0)325
[DOI]
51Chrysin treatment improves diabetes and its complications in liver, brain, and pancreas in streptozotocin-induced diabetic rats
Saeed Samarghandian,Mohsen Azimi-Nezhad,Fariborz Samini,Tahereh Farkhondeh
Canadian Journal of Physiology and Pharmacology.2016;94(4)388
[DOI]
52Immunomodulatory and antioxidant effects of saffron aqueous extract ( Crocus sativus L.) on streptozotocin-induced diabetes in rats
Saeed Samarghandian,Mohsen Azimi-Nezhad,Tahereh Farkhondeh
Indian Heart Journal.2017;69(2)151
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53TMPE Derived from Saffron Natural Monoterpene as Cytotoxic and Multidrug Resistance Reversing Agent in Colon Cancer Cells
Kamila Sroda-Pomianek,Anna Palko-Labuz,Andrzej Pola,Miroslawa Ferens-Sieczkowska,Olga Wesolowska,Agata Koziol
International Journal of Molecular Sciences.2020;21(20)7529
[DOI]
54TMPE Derived from Saffron Natural Monoterpene as Cytotoxic and Multidrug Resistance Reversing Agent in Colon Cancer Cells
Amélia Martins Delgado,Salvatore Parisi,Maria Daniel Vaz Almeida
International Journal of Molecular Sciences.2017;21(20)59
[DOI]
55Antiproliferative Activity of Crocin Involves Targeting of Microtubules in Breast Cancer Cells
Rupali R. Hire,Shalini Srivastava,Melissa B. Davis,Ananda Kumar Konreddy,Dulal Panda
Scientific Reports.2017;7(1)59
[DOI]
56Crocus sativus restores dopaminergic and noradrenergic damages induced by lead in Meriones shawi: A possible link with Parkinson’s disease
Lahcen Tamegart,Abdellatif Abbaoui,Rachida Makbal,Mohamed Zroudi,Brahim Bouizgarne,My Mustapha Bouyatas,Halima Gamrani
Acta Histochemica.2019;121(2)171
[DOI]
57Phytochemical Differentiation of Saffron (Crocus sativus L.) by High Resolution Mass Spectrometry Metabolomic Studies
Evangelos Gikas,Nikolaos Stavros Koulakiotis,Anthony Tsarbopoulos
Molecules.2021;26(8)2180
[DOI]
58Honey as a Natural Alternative for Formalin Fixative - A Systematic Review
Snega Thamilselvan,Don K. R,Herald J. Sherlin,Gifrina Jayaraj,Archana Santhanam
Journal of Evolution of Medical and Dental Sciences.2021;10(6)369
[DOI]
59Safranal epoxide – A potential source for diverse therapeutic applications
Suzan Khayyat,Eman Elgendy
Saudi Pharmaceutical Journal.2018;26(1)115
[DOI]
60Drug–DNA interaction, a joint DFT-D3/MD study on safranal as an anticancer and DNA nanostructure model
Ebrahim Azarhazin,Mohammad Izadyar,Mohammad Reza Housaindokht
Canadian Journal of Chemistry.2019;97(2)120
[DOI]
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