%0 Journal Article %J Pharmacognosy Research %D 2021 %T In-silico Molecular Docking Studies of some Isolated Phytochemicals from Biophytum veldkampii against Cyclooxygenase-II Enzyme and in vivo Anti-inflammatory Activity %A Nagaraju Bandaru %A D.S.N.B.K Prasanth %A A.Rajasekhar Reddy %A G.S.N Koteswara Rao %A Kumar V.S Nemmani %A Alla Narayana Rao %K 2 %K 3’ %K 4’-Tetrahydroxy-2 benzylcoumaranone %K 6 %K Autodock4.0 %K Carageenan %K Cyclooxygenase II %K In-silico %K Inflammation %K Phytochemical %X

Background: The current study estimate the anti-inflammatory activity of whole plant of Biophytum veldkampii on carageenan induced inflammation on rats compiled by molecular docking studies of phytocompounds from the plants with Cyclooxygenase II (PDB ID: 3LN1). Methods: In this research Biophytum veldkampii was subjected to extraction using methanol. In-vivo anti-inflammatory activity was assessed by using carageenan induced inflammation on rats and in-silico molecular docking studies was performed by using of Autodock 4.0. Results: The outcomes revealed that the methanolic extract has most prominenant anti-inflammatory activity at various doses. Among all the substances 2,6,3’,4’-Tetrahydroxy-2-benzylcoumaranone revealed the most effective docking rating of -6.8, which is near to Diclofenac, i.e. - 6.9, ensuring that 2,6,3’,4’-Tetrahydroxy-2-benzylcoumaranone has a strong binding fondness in between protein and ligand. Conclusion: From the results, a conclusion can be drawn that the anti-inflammatory activity of Biophytum veldkampii in both in vivo and in silico methods. This information sustains 2,6,3’,4’-Tetrahydroxy-2-benzylcoumaranone to be a useful anti-inflammatory compound beneficial to future clinical studies.

%B Pharmacognosy Research %V 13 %P 192-198 %8 October 2021 %G eng %N 4 %9 Original Article %& 192 %R 10.5530/pres.13.4.11