%0 Journal Article %J Pharmacognosy Research %D 2014 %T Margaritaria Discoidea (Euphorbiaceae) Stem Bark Extract Attenuates Allergy and Freund's adjuvant-induced Arthritis in Rodents %A David D Obiri %A Newman Osafo %A Joshua Oppong-Sarfo %A Jude K Prah %K Allergy %K Anaphylaxis %K Anti-inflammatory %K Arthritis %K Margaritaria discoidea %X

Background: Various parts of Margaritaria discoidea find use in traditional medicine in the treatment of pain and oedema. This study evaluated the anti-allergic, anti-inflammatory and anti-arthritic effects of a 70% (v/v) aqueous ethanol extract of the stem bark of Margaritaria discoidea, MDE in rodents. Materials and Methods: Systemic anaphylaxis was induced by the injection of compound 48/80 into mice and their survival rate was monitored to evaluate the anti-allergic action of the extract. The effect of MDE assessed on the maximal and total oedema responses in the mouse carrageenan-induced paw oedema was used to evaluate the anti-inflammatory action of the extract while the Freund's adjuvant-induced arthritis model was employed to study the anti-arthritic effects of MDE. Results: MDE dose-dependently increased the time for compound 48/80-induced mortality in mice. MDE suppressed the mean maximal swelling and the total paw swellings induced over 6 h in the carrageenan-induced paw oedema when administered either prophylactically or therapeutically. MDE caused a reduction in serum levels of TNFα and IL-6 and significantly suppressed Freund's adjuvant-induced arthritis. Conclusion: Margaritaria discoidea suppresses allergy and exhibits anti-inflammatory activity in mice. In addition it attenuates Freund's adjuvant-induced arthritis through a reduction in serum levels of TNFα and IL-6 in rats.

%B Pharmacognosy Research %V 6 %P 163-171 %8 March,2014 %G eng %N 2 %9 Original Article %& 163 %R 10.4103/0974-8490.129039