TY - JOUR T1 - Hepatoprotective Effect of Poly Herbal Formulation Against Various Hepatotoxic Agents in Rats JF - Pharmacognosy Research Y1 - 2012 A1 - Anil U Tatiya A1 - Sanjay J Surana A1 - Manisha P Sutar A1 - Nehal H Gamit KW - Andrographis paniculata Nees KW - Carbon tetrachloride KW - Hepatoprotective activity KW - Marker enzymes KW - Paracetamol KW - Phyllanthus niruri Linn AB -

Background: Individually Andrographis paniculata Nees. (Acanthaceae), Phyllanthus niruri Linn.(Euphorbiaceae) and Phyllanthus emblica Linn. single plant extracts have been reported to have hepatoprotective activity. However, literature survey shows that no sufficient scientific data has been publish on pharmacological evaluation of these plants in combined form. Materials and Methods: Hepatoprotective activity of the polyherbal hepatoprotaective formulation (PHF)-containing spray-dried aqueous extracts of Andrographis paniculata Nees. (Acanthaceae), Phyllanthus niruri Linn. (Euphorbiaceae) and Phyllanthus emblica Linn. (Euphorbiaceae), was screened against paracetamol, carbon tetrachloride (CCl 4 ), and ethanol-induced hepatic damage in rats. PHF was evaluated by measuring levels of serum marker enzymes like SGOT, SGPT, ALP, direct bilirubin (DB), and lactate dehydrogenase (LDH). The histological studies were also studied support the biochemical parameters. Silymarin was used as standard drug. Results: Administration of PHF (100 and 200 mg/kg p.o.) significantly inhibited paracetamol, CCl 4 and ethanol-induced elevation levels of SGPT, SGOT, ALP, DB and LDH. A comparative histopathological study of liver exhibited almost normal architecture as compared to toxicant group. Conclusion: Results suggests that the hepatoprotective effects of PHF might be useful for liver protection due to combined action of all plant extracts along with their phytoconstituents.

VL - 4 IS - 1 ER -