01938nas a2200217 4500008004100000245011900041210006900160260001400229300001200243490000600255520117900261653004301440653003601483653002001519653002601539653001901565100002401584700002201608700002301630856006701653 2011 eng d00aImmunomodulatory and Erythropoietic Effects of Aqueous Extract of the Fruits of Solanum Torvum Swartz (Solanaceae)0 aImmunomodulatory and Erythropoietic Effects of Aqueous Extract o cJune,2011 a130-1340 v33 a

Aim: The effect of Solanum torvum (Fam: Solanaceae) on delayed type hypersensitivity (DTH) response, hemagglutinating antibody (HA) titer, white blood cells (WBC), red blood cells (RBC) and hemoglobin concentration was investigated in Sprague-Dawley rats to establish immunomodulatory and erythropoietic activity. Materials and Methods: Sheep red blood cells (SRBC)-immunized and challenged rats were treated with Solanum torvum extract, levamisole and dexamethasone. Phenylhydrazine (PHZ)-induced anemia in rats was treated with the extract. Results: The aqueous Solanum torvum extract and levamisole significantly enhanced DTH response, increased HA titer and WBC count, while dexamethasone significantly decreased DTH response, did not increase HA titer, and did not enhance WBC profile. The extract and Feroglobin, the reference heamatinic, were able to reverse PHZ-induced anemia, and increase the RBCs and Hb concentration above baseline values within 24 days. Conclusion: Solanum torvum extract showed a concentrationdependent immunostimulant and erythropoietic activity.

10aDelayed type hypersensitivity response10aHemagglutinating antibody titer10aPhenylhydrazine10aSheep red blood cells10aSolanum torvum1 aKoffuor, George, A.1 aAmoateng, Patrick1 aAndey, Terrick, A. uhttps://www.phcogres.com/article/2011/3/2/1041030974-849081961