02580nas a2200277 4500008004100000245010700041210006900148260001900217300001200236490000600248520166000254653001601914653002001930653001901950653001901969653001701988100002502005700002002030700002702050700003102077700002902108700002602137700003102163700004102194856006702235 2011 eng d00aAmelioration of nitrobenzene-induced nephrotoxicity by the ethanol extract of the herb Euphorbia hirta0 aAmelioration of nitrobenzeneinduced nephrotoxicity by the ethano cSeptember 2011 a201-2070 v33 a

Background: Euphorbia hirta (L.) (Euphorbiaceae) is a very popular herb amongst practitioners of traditional medicine and used in the treatment of female disorders, respiratory ailments, tumors, jaundice, digestive problems, wounds, etc. We aimed to evaluate the protective effect of E. hirta against nitrobenzene-induced nephrotoxicity in albino rats. Materials and Methods: The nephroprotective activity of the ethanol extract of E. hirta (400 mg/kg body weight) was studied in nitrobenzene-induced albino rats (1000 mg/kg body weight). The activities of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST), and the levels of reduced glutathione (GSH), total thiols and vitamin C in the kidney tissues were determined. Histopathologic investigation was performed in the kidney tissue samples. Results: Nitrobenzene administration significantly (P < 0.01) enhanced the lipid peroxidation and significantly (P < 0.05) depleted the levels of SOD, CAT, GPx, GST, GSH, total thiols and vitamin C. Treatment with the ethanol extract of E. hirta significantly normalized the antioxidant levels. The nephroprotective activity was also supported by histopathologic studies of kidney tissue. Conclusion: The results indicate that the ethanol extract of E. hirta ameliorates renal dysfunction and could be used as an effective protector against nitrobenzene-induced nephrotoxicity, primarily through its antioxidant capacity.

10aAntioxidant10aEuphorbia hirta10aHistopathology10aNephrotoxicity10anitrobenzene1 aSuganya, Subramanian1 aSophia, Dominic1 aRaj, Chinthamony, Arul1 aRathi, Muthaiyan, Ahalliya1 aThirumoorthi, Lakshmanan1 aMeenakshi, Periyasamy1 aKumar, Dugganaboyana, Guru1 aGopalakrishnan, Velliyur, Kanniyapan uhttps://www.phcogres.com/article/2011/3/3/1041030974-849085009