02373nas a2200193 4500008004100000245009900041210006900140260001800209300001200227490000600239520177300245653002302018653001402041653001702055653001502072100001802087700002102105856005302126 2009 eng d00aAntiulcer Activity of Methanol Extract of Erythrina indica Lam. Leaves in Experimental Animals0 aAntiulcer Activity of Methanol Extract of Erythrina indica Lam L cJanuary 2010  a396-4010 v13 a

Gastric ulcer is one of the most prevalent gastrointestinal disorders, which affects approximately 5–10% of people during their life. In recent years, abundant work has been carried out on herbal medicine to clarify their potential efficacy in gastric ulcer prevention or management. Here, present study was carried out to investigate antiulcer activity of methanol extract of Erythrina indica (family: Febaceae) leaves in pylorus ligated and indomethacin induced ulceration in the albino rats. Preliminary methanol extract of E. indica was subjected to the acute oral toxicity study according to the OECD guideline no. 423. Based on which, three dose levels i.e. 125, 250 and 500mg/kg were selected for the further study. In pylorus ligation induced ulcer model, various parameters were studied viz. gastric volume, pH, total acidity free acidity, and ulcer index. Ulcer index and percentage inhibition of ulceration was determined for indomethacin induced ulcer model. Ranitidine at 100mg/kg was used as the standard drug. Pretreatment of methanol extract of E. indica leaves showed significant (P<0.01) decrease in the gastric volume, total acidity and free acidity. However, pH of the gastric juice was significantly (P<0.05) increased only at higher dose, 500mg/kg. It showed also significant (P<0.01) decrease in number of ulcers and ulcer score index in pylorus ligation and indomethacin induced ulceration models. The methanol extract of E. indica leaves possess significant antiulcer properties in a dose dependent manner. In conclusion the antiulcer properties of the extract may be attributed to the polyphenolic compounds that are present in it.

10aAntiulcer activity10aE. indica10aIndomethacin10aranitidine1 aSachin, Sakat1 aArchana, Juvekar uhttps://www.phcogres.com/article/2009/1/6/nil-10