02420nas a2200205 4500008004100000245011300041210006900154260001900223300001200242490000600254520176000260653002202020653001402042653001602056653001402072653002002086100002102106700002002127856006702147 2010 eng d00aA Study of the Anti-inflammatory Effect of the Leaves of Psidium guajava Linn. on Experimental Animal Models0 aStudy of the Antiinflammatory Effect of the Leaves of Psidium gu cNovember 2010 a313-3170 v23 a

Introduction : The aim is to study the anti-inflammatory effect of the ethanolic extract of the leaves of Psidium guajava (PGE) on experimental animal models. Materials and Methods : Fresh leaves were collected, air-dried, powdered, and percolated in 95% ethanol. Acute toxicity test was done according to OECD guidelines. Four groups of animals of either sex, weighing 150-200g of the species Rattus norvegicus were taken for the study (n = 6). Group A was taken as control (3% gum acacia in 10 mL/kg body weight), Group B as test group (PGE 250 mg/kg body weight), Group C as test group (PGE 500 mg/kg body weight), and Group D as standard (Aspirin 100 mg/kg body weight). The animals were studied for acute inflammation by Carrageenan-induced rat paw edema, subacute inflammation by Granuloma pouch method, and chronic inflammation by Freund's adjuvant-induced arthritis method. Statistical analysis was done by one-way analysis of variance followed by multiple comparison tests. Results : In acute inflammation, there was significant inhibition of paw edema in Groups B, C, and D in comparison with Group A (P < 0.05). In subacute inflammation, there was significant inhibition of exudate formation in Groups B, C, and D in comparison to Group A (P < 0.05). In chronic inflammation, there was significant inhibition of paw edema and inhibition of weight reduction in Groups B, C, and D compared with Group A. Downregulation of arthritis index was also significant in Groups B, C, and D in comparison with Group A (P < 0.05). Conclusion : The ethanolic extract of PGE has significant anti-inflammatory activity.

10aAnti-inflammatory10aArthritis10aCarrageenan10aGranuloma10aPsidium guajava1 aDutta, Sarmistha1 aDas, Swarnamoni uhttps://www.phcogres.com/article/2010/2/5/1041030974-849072331