01846nas a2200229 4500008004100000245011900041210006900160260001900229300001200248490000600260520107000266653002401336653001701360653002901377100002001406700002301426700002801449700002301477700002101500700002801521856006701549 2010 eng d00aBrine shrimp Lethality and Acute Oral Toxicity Studies on Swietenia mahagoni (Linn.) Jacq. seed Methanolic Extract0 aBrine shrimp Lethality and Acute Oral Toxicity Studies on Swiete cSeptember 2010 a215-2200 v23 a

Background: The seeds of Swietenia mahagoni have been applied in folk medicine for the treatment of hypertension, diabetes, malaria, amoebiasis, cough, chest pain, and intestinal parasitism. Here we are the first to report on the toxicity of the Swietenia mahagoni crude methanolic (SMCM) seed extract. Methods: SMCM seed extract has been studied for its brine shrimp lethality and acute oral toxicity, in mice. Results: The brine shrimp lethality bioassay shows a moderate cytotoxicity at high concentration. The LC50 for the extract is 0.68 mg/ml at 24 hours of exposure. The LD50 of the SMCM seed extract for acute oral toxicity in mice is greater than 5000 mg/kg. Conclusion: This study demonstrates that Swietenia mahagoni crude methanolic seed extract may contain bioactive compounds of potential therapeutic significance which are relatively safe from toxic effects, and can compromise the medicinal use of this plant in folk medicine.

10aAcute oral toxicity10aBrine shrimp10aSwietenia mahagoni seeds1 aSahgal, Geethaa1 aRamanathan, Surash1 aSasidharan, Sreenivasan1 aMordi, Mohd, Nizam1 aIsmail, Sabariah1 aMansor, Sharif, Mahsufi uhttps://www.phcogres.com/article/2010/2/4/1041030974-849069107