02544nas a2200229 4500008004100000245011100041210006900152300001300221490000600234520173200240653002901972653001802001653001702019653002102036100003002057700003002087700002702117700003402144700003502178700003302213856006802246 2014 eng d00aPhytochemical Screening and Anti-inflammatory Activity of Cnidoscolus quercifolius (Euphorbiaceae) in Mice0 aPhytochemical Screening and Antiinflammatory Activity of Cnidosc a 345-3490 v63 a

Background: Cnidoscolus quercifolius is a species popularly known as "favela" and "faveleira", and belonging to the Caatinga biome (semi-arid vegetation, Brazil), where is used in folk medicine as an anti-inflammatory. Objective: The aim was to evaluate the anti-inflammatory effect of the ethanolic extract from barks (Cqb-EtOH) and leaves (Cql-EtOH) of C. quercifolius in mice using experimental models of inflammation. Materials and Methods: The preliminary phytochemical analysis of the ethanolic extract was performed. The activity was evaluated by paw edema induced by carrageenan and leukocytes migration to the peritoneal cavity induced by carrageenan methods. Results: A preliminary analysis of Cqb-EtOH revealed that it contained coumarins, flavonoids, monoterpenes/diterpenes and naphthoquinones, while the Cql-EtOH showed positive reaction to coumarins, anthracene derivatives, flavonoids, lignans and triterpenes/steroids. Cqb-EtOH and Cql-EtOH (100, 200 and 400 mg/kg) inhibited significantly (P < 0.01) the increase in the edema volume after administration of carrageenan. In the peritonitis test, acute pretreatment with Cqb-EtOH and Cql-EtOH (100, 200 and 400 mg/kg) inhibited the leukocyte migration. Conclusions: It can be concluded that extracts from the barks and leaves of C. quercifolius have anti-inflammatory activity, which supports the popular use of this plant to treat inflammation. Thus, extracts has significant anti-inflammatory properties, which are related probably to inhibition of release of mediators of the inflammatory process.

10aCnidoscolus quercifolius10aEuphorbiaceae10aInflammation10aMedicinal plants1 aGomes, Leandra, Macedo de1 aGomes, Leandra, Macedo de1 aSilva, Juliane, Cabral1 ade Lima, Julianeli, Tolentino1 aQuintans-Junior, Lucindo, Jose1 aAlmeida, Jackson, Roberto Gu uhttps://www.phcogres.com/article/2014/6/4/1041030974-8490138290