02613nas a2200229 4500008004100000245012900041210006900170260001400239300001200253490000600265520186400271653001802135653001502153653002202168653002202190653002102212100002402233700002002257700001902277700002002296856006702316 2010 eng d00aAntifungal, Antibacterial and Antimycobacterial Activity of Entada abysinnica Steudel ex A. Rich (Fabaceae) Methanol Extract0 aAntifungal Antibacterial and Antimycobacterial Activity of Entad cJuly 2010 a163-1680 v23 a

The purpose of the study was to investigate the antifungal, antibacterial and antimycobacterial properties of methanol extract of Entada abysinnica steudel ex. A. Rich (Fabaceae) leaves used by herbalists from the Lake Victoria region, Kenya. The extract was tested against four strains of mycobacteria (Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium fortuitum, and Mycobacterium smegmatis) using BACTEC Mycobacteria Growth Indicator Tube (MGIT) 960 system and the proportional method. Standard procedures were used to determine the zones of inhibition, minimum inhibitory concentrations (MICs) and minimum bactericidal/fungicidal concentrations (MBCs/MFCs) for Candida albicans, Salmonella typhi, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae. The extract showed activity against some mycobacteria strains, especially M. tuberculosis. It also showed strong antimicrobial activity (zones of inhibition were between 9.00 and 14.10 mm) against C. albicans, Sa. typhi, and St. aureus. The extract gave a better zone of inhibition against C. albicans than fluconazole whose zone of inhibition was 13.00 mm. The MICs and MBCs for C. albicans and Sa. typhi were good. The crude extracts were also analyzed for the presence of phytochemicals. Phytochemical screening indicated that the extract most abundantly contained tannins, saponins, and flavonoids. The data suggest that the methanolic leaves extract of E. abysinnica could be a rich source of antimicrobial agents, especially antifungals. The results further show that there is some merit in the use of the plant in alternative medical practices. However, bioassays of isolated compounds are underway and will be reported during subsequent communications

10aAntibacterial10aAntifungal10aAntimycobacterial10aEntada abysinnica10aMethanol extract1 aMariita, Richard, M1 aOrodho, John, A1 aOkemo, Paul, O1 aMbugua, Paul, K uhttps://www.phcogres.com/article/2010/2/3/1041030974-849065511