01760nas a2200205 4500008004100000245007700041210006900118260001400187300001200201490000700213520115100220653001501371653001701386653001201403653001601415653001901431653001901450100002301469856006201492 2021 eng d00aStatistical Evaluation and Characterization of Carica papaya Metabolites0 aStatistical Evaluation and Characterization of Carica papaya Met cJune 2021 a129-1340 v133 a

Background: Natural resources are often sought for potential molecules which are pharmacologically active. Carica papaya is a well-known plant, studied for its constituent secondary metabolites and their benefits. Methods: This study focuses on identifying low molecular weight secondary metabolites form Carica papaya as potential pharmacophores, based on their structure. We determined their similarity with pharmaceutically active anti-clotting molecules using clustering method. Cheminformatic and Statistical analysis was done with data on molecular characteristics. Results: We have identified Carica papaya compounds to be pharmacologically active. In this study, we have differentiated Carica papaya compounds, through statistical analysis using clustering method, on the basis of significant molecular properties. Conclusion: Molecular similarity of secondary metabolites revealed through this study identifies, Carica papaya metabolites as a possible substitute drug and a preventive medicine against thrombosis.

10aClustering10aDruglikeness10aLigands10aMetabolites10aPhytochemistry10aThrombogenesis1 aMeleveetil, Vidhya uhttps://www.phcogres.com/article/2021/13/3/105530pres1334