01880nas a2200217 4500008004100000245009300041210006900134260001300203300001000216490000600226520118600232653001301418653003001431653002801461100001801489700002301507700002101530700002001551700002401571856006701595 2010 eng d00aDiuretic activity of Leaves of Plectranthus amboinicus (Lour) Spreng in Male Albino Rats0 aDiuretic activity of Leaves of Plectranthus amboinicus Lour Spre cMay 2010 a86-880 v23 a

The shade-dried powder of leaves of Plectranthus amboinicus (Lour) Spreng was subjected to successive extraction using the various solvents (petroleum ether, chloroform, ethanol and water) in increasing order of polarity. The preliminary phytochemical analyses were carried out for all the extracts. The analyses of the leaves revealed the presence of alkaloids, carbohydrates, glycosides, proteins, amino acids, flavonoids, quinine, tannins, phenolic compounds and terpenoids. Since the phytoconstituents present in the ethanolic and aqueous extracts were similar, both the extracts were selected for further study. The diuretic properties of ethanolic and aqueous extracts were evaluated by determination of urine volume and electrolyte concentration in male albino rats. Furosemide (10 mg/kg) was used as standard while normal saline (0.9%) was used as control. Both ethanolic and aqueous extracts (500 mg/kg) have shown significant increase in the volume of urine and urinary concentration of Na, K and Cl ions. Thus, from the is study it may be concluded that the leaves of P. amboinicus (Lour) Spreng possess diuretic activities.

10aDiuretic10aElectrolyte concentration10aPlectranthus amboinicus1 aPatel, Roshan1 aMahobia, Naveen, K1 aGendle, Ravindra1 aKaushik, Basant1 aSingh, Sudarshan, K uhttps://www.phcogres.com/article/2010/2/2/1041030974-849062956