01491nas a2200217 4500008004100000245010100041210006900142260001500211300001000226490000600236520083500242653001901077653001501096653002301111653001501134100001401149700001401163700001601177700001301193856006701206 2010 eng d00aAnticonvulsant and Anxiolytic Evaluation of Leaf Extracts of Ocimum gratissimum, a Culinary Herb0 aAnticonvulsant and Anxiolytic Evaluation of Leaf Extracts of Oci cMarch 2010 a36-400 v23 a
Anticonvulsant and anxiolytic activities of leaf extracts and fraction of Ocimum gratissimum L. (Lamiaceae) were studied using seizures induced by pentylenetetrazol and open-field tests in mice. The results showed that the extracts and fraction increased the latency of tonic and tonic-clonic seizures and death and elicited 50% protection against mortality. In the open-field test, the extracts and fraction decreased the frequency of line crossing, center square entries, rearing against a wall and grooming, whereas grooming duration and freezing frequency and duration were increased. Acute toxicity test in mice gave an oral LD 50 greater than 5000 mg/kg for the methanol extract. These findings suggest that extracts of this plant possess anticonvulsant and anxiolytic-like properties.
10aAnticonvulsant10aAnxiolytic10aOcimum gratissimum10aOpen field1 aOkoli, CO1 aEzike, AC1 aAgwagah, OC1 aAkah, PA uhttps://www.phcogres.com/article/2010/2/1/1041030974-849060580