01603nas a2200205 4500008004100000245011100041210006900152260001500221300001000236490000600246520094200252653002001194653002101214653001901235653001601254100002201270700002301292700001501315856006701330 2010 eng d00aProtective Effect of Stem Bark of Ceiba pentandra linn. against Paracetamol-induced Hepatotoxicity in Rats0 aProtective Effect of Stem Bark of Ceiba pentandra linn against P cMarch 2010 a26-300 v23 a

The present study reports protective activity of ethyl acetate fraction of methanol extract of stem bark of Ceiba pentandra against paracetamol-induced liver damage in rats. The ethyl acetate fraction (400 mg/kg) was administered orally to the rats with hepatotoxicity induced by paracetamol (3 gm/kg). Silymarin (100 mg/kg) was used as positive control. High performance thin layer chromatography (HPTLC) fingerprinting of ethyl acetate fraction revealed presence of its major chemical constituents. A significant (P < 0.05) reduction in serum enzymes GOT (ALT), aspartate aminotransferase (AST), GPT alkaline phosphatase (ALP), total bilirubin content and histopathological screening in the rats treated gave indication that ethyl acetate fraction of methanolic extract of Ceiba pentandra possesses hepatoprotective potential against paracetamol-induced hepatotoxicity in rats.

10aCeiba pentandra10aHepatoprotective10aHepatotoxicity10aParacetamol1 aBairwa, Nirmal, K1 aSethiya, Neeraj, K1 aMishra, SH uhttps://www.phcogres.com/article/2010/2/1/1041030974-849060584