01949nas a2200205 4500008004100000245010100041210006900142260001500211300001000226490000600236520132000242653002001562653001701582653001101599653002001610100001401630700001301644700001901657856006701676 2011 eng d00aThe study of aqueous extract of Ficus religiosa Linn. on cytokine TNF-α in type 2 diabetic rats0 astudy of aqueous extract of Ficus religiosa Linn on cytokine TNF cApril 2011 a30-340 v33 a

Background: Chronic systemic inflammation is an early process in pathogenesis of type 2 diabetes. Hence the present study was aimed to investigate the effect of traditionally known plant Ficus religiosa on elevated glucose and inflammatory marker namely tumor necrosis factor (TNF)-α in type 2 diabetic rats. Methods: Type 2 diabetes was induced by administering streptozotocin (90 mg/kg, i.p.) in neonatal rat model. Aqueous extract of F. religiosa at a dose of 100 and 200 mg/kg was given orally to desired group of animals for a period of 4 weeks. After 4 weeks of drug treatment, parameters such as fasting blood glucose, postprandial blood glucose and TNF-α in serum were analyzed. Results: Aqueous extract of F. religiosa at both dose levels i.e., 100 and 200 mg/kg decreased the elevated glucose and TNF-α in type 2 diabetic rats. The extract at 200 mg/kg had more pronounced effect. Conclusion: Modulation of cytokine TNF-α by the aqueous extract of F. religiosa indicates that the anti-inflammatory and immunomodulatory property of the plant is related with its potential anti-diabetic activity.

10aFicus religiosa10aInflammation10aTNF-α10atype 2 diabetes1 aKirana, H1 aJali, MV1 aSrinivasan, BP uhttps://www.phcogres.com/article/2011/3/1/1041030974-849079112