02991nas a2200277 4500008004100000245016900041210006900210260001500279300001200294490000600306520207700312653000602389653003302395653001202428653002502440653001802465653002802483653002102511100002002532700001902552700001702571700001802588700001902606700002002625856006802645 2014 eng d00aComparative Study of Antidiabetic activity of Cajanus Cajan and Tamarindus indica in Alloxan-induced Diabetic Mice with a Reference to In vitro Antioxidant Activity0 aComparative Study of Antidiabetic activity of Cajanus Cajan and  cMarch,2014 a180-1870 v63 a

Background: Oxidative stress not only develops complications in diabetic (type 1 and type 2) but also contributes to beta cell destruction in type 2 diabetes in insulin resistance hyperglycemia. Glucose control plays an important role in the pro-oxidant/antioxidant balance. Some antidiabetic agents may by themselves have antioxidant properties independently of their role on glucose control. Objective: The present investigation draws a comparison of the protective antioxidant activity, total phenol content and the antihyperglycemic activity of the methanolic extract of Cajanus cajan root (MCC) and Tamarindus indica seeds (MTI). Materials and Methods: Antidiabetic potentials of the plant extracts were evaluated in alloxan-induced diabetic Swiss albino mice. The plant extracts at the doses of 200 and 400 mg/kg body weight was orally administered for glucose tolerance test during 1-hour study and hypoglycemic effect during 5-day study period in comparison with reference drug Metformin HCl (50 mg/kg). In vitro antioxidant potential of MCC and MTI was investigated by using 1, 1- diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity at 517 nm. Total phenolic content, total antioxidant capacity and reducing power activity was also assayed. Results: There was a significant decrease in fasting serum glucose level (P < 0.001), reduction in blood glucose level (P < 0.001) in 5-days study, observed in the alloxan-induced diabetic mice. The reduction efficacy of blood glucose level of both the extracts is proportional to their dose but MCC is more potent than MTI. Antioxidant study and quantification of phenolic compound of both the extracts revealed that they have high antioxidant capacity. Conclusion: These studies showed that MCC and MTI have both hypoglycemic and antioxidant potential but MCC is more potent than MTI. The present study suggests that both MCC and MTI could be used in managing oxidative stress.

10a110a1- diphenyl-2-picrylhydrazyl10aAlloxan10aAntioxidant activity10aHyperglycemia10aMetformin hydrochloride10aOxidative stress1 aNahar, Laizuman1 aNasrin, Fatema1 aZahan, Ronok1 aHaque, Anamul1 aHaque, Ekramul1 aMosaddik, Ashik uhttps://www.phcogres.com/article/2014/6/2/1041030974-8490129043