02104nas a2200205 4500008004100000245008900041210006900130260001800199300001000217490000600227520147100233653002801704653001901732653001401751653001701765100001901782700002001801700002501821856005201846 2009 eng d00aThe Effect of Extracts of Andrographis paniculata Aerial Parts on Rat Thoracic Aorta0 aEffect of Extracts of Andrographis paniculata Aerial Parts on Ra cJanuary 2010  a60-650 v13 a

Andrographis paniculata (AP), (Burf.) Nees. of Acanthaceae, has been used for centuries in Asia to treat GI tract and upper respiratory tract infections, fever, herpes, sore throat, and a variety of other chronic and infectious diseases. AP has cardio protective property and is familiarly known as "King of Bitters". The present study was aimed to investigate the vasorelaxant effect of different solvent extracts of AP on rat thoracic aorta. Petroleum ether, chloroform, and methanol extracts of AP are used in this study. Experiments are performed on male Sprague-Dawley (SD) rats for possible vasorelaxing activity of AP. Cumulative dose response curves are recorded by using isometric force displacement transducer Model FT-03 and it is connected to Grass Polygraph Model 79D. Additionally, HPLC study of chloroform extract of AP is conducted and compared with commercially available standard andrographolide. Petroleum ether and chloroform extract of AP is first suspended in 1% (v/v) DMSO then volume made up with Krebs solution. The average of responses to each concentration of the agonist is plotted on the ordinate the logarithm of the concentration of the agonist on the abscissa. Among all these extracts of AP, chloroform extract 80 and 160 9g/mL is found to be the highly significant (P<0.001) vasorelaxant effect on norepinephrine induced contraction on rat thoracic aortic ring preparations.

10aAndrographis paniculata10aNorepinephrine10aRat aorta10aVasorelaxant1 aNaidu, Raghava1 aSadikun, Amirin1 aAsmawi, Mohd., Zaini uhttps://www.phcogres.com/article/2009/1/2/nil-1