02730nas a2200313 4500008004100000245015200041210006900193260001800262300001000280490000700290520169000297653002401987653002102011653002502032653001902057653002602076653002402102100002302126700002302149700002202172700002002194700002102214700002202235700001902257700002302276700002502299700003002324856006202354 2020 eng d00aGhanaian Herbal Medicines for Malaria: An Evaluation of the Clinical Safety and Effectiveness of “Time Herbal Mixture” in Uncomplicated Malaria0 aGhanaian Herbal Medicines for Malaria An Evaluation of the Clini cFebruary 2020 a71-750 v123 a

Background: Herbal antimalarials have become a popular source of treatment for most Ghanaians. The significant increase in patronage is of public health concern due to the lack of quality, safety, and efficacy data. Aim: In this report, we evaluated the clinical safety and effectiveness of a Ghanaian commercial product named “Time Herbal Mixture” (THM). The product is formulated from the leaves of Solanum torvum and Vernonia amygdalina and the stem bark of Spathodea campanulata and Bombax buonopozense. Methods: Participants of 40 patients diagnosed with uncomplicated malaria were recruited, treated, and followed up for a period of 28 days. This population comprised 25 (62.50%) females and 15 (37.50%) males, with a mean age of 42.29 (12.35) years. Outcome of primary interest was the ability of the product to clear blood parasites by day 7 of the study, resolution of cardinal symptoms of malaria, and an absence of adverse effects from the use of the product. Results and Discussion: A total of 33 (82.50%) participants achieved clearance of all parasites by day 7 (complete cure). Partial clearance was attained by 6 (15.0%) and treatment failure in 1 (2.50%). Resolution of the cardinal symptoms was also observed in most participants by day 7. The product also had a good safety profile as none of the participants reported any adverse effects. Liver, kidney, and hematological profiles were also normal after the study. Conclusion: “THM,” therefore, has the potential to be used in cases of uncomplicated malaria.

10aBombax buonopozense10aClinical studies10aHerbal antimalarials10aSolanum torvum10aSpathodea campanulata10aVernonia amygdalina1 aTetteh, Andrews, W1 aThomford, Kwesi, P1 aMensah, Merlin, L1 aBoadu, Kwame, O1 aThomford, Ama, K1 aAmposah, Isaac, K1 aAmofa, Godfred1 aTurkson, Benard, K1 aAgyemang, Michael, O1 aOwusu-Ansah, Emmanuel, DJ uhttps://www.phcogres.com/article/2020/12/1/104103prpr2319