02464nas a2200241 4500008004100000245009800041210006900139260001800208300001000226490000600236520167800242653003301920653002501953653003001978653001902008653001602027653002802043100002002071700002202091700002202113700002002135856006702155 2012 eng d00aHepatoprotective Effect of Poly Herbal Formulation Against Various Hepatotoxic Agents in Rats0 aHepatoprotective Effect of Poly Herbal Formulation Against Vario cdecember,2011 a50-560 v43 a

Background: Individually Andrographis paniculata Nees. (Acanthaceae), Phyllanthus niruri Linn.(Euphorbiaceae) and Phyllanthus emblica Linn. single plant extracts have been reported to have hepatoprotective activity. However, literature survey shows that no sufficient scientific data has been publish on pharmacological evaluation of these plants in combined form. Materials and Methods: Hepatoprotective activity of the polyherbal hepatoprotaective formulation (PHF)-containing spray-dried aqueous extracts of Andrographis paniculata Nees. (Acanthaceae), Phyllanthus niruri Linn. (Euphorbiaceae) and Phyllanthus emblica Linn. (Euphorbiaceae), was screened against paracetamol, carbon tetrachloride (CCl 4 ), and ethanol-induced hepatic damage in rats. PHF was evaluated by measuring levels of serum marker enzymes like SGOT, SGPT, ALP, direct bilirubin (DB), and lactate dehydrogenase (LDH). The histological studies were also studied support the biochemical parameters. Silymarin was used as standard drug. Results: Administration of PHF (100 and 200 mg/kg p.o.) significantly inhibited paracetamol, CCl 4 and ethanol-induced elevation levels of SGPT, SGOT, ALP, DB and LDH. A comparative histopathological study of liver exhibited almost normal architecture as compared to toxicant group. Conclusion: Results suggests that the hepatoprotective effects of PHF might be useful for liver protection due to combined action of all plant extracts along with their phytoconstituents.

10aAndrographis paniculata Nees10aCarbon tetrachloride10aHepatoprotective activity10aMarker enzymes10aParacetamol10aPhyllanthus niruri Linn1 aTatiya, Anil, U1 aSurana, Sanjay, J1 aSutar, Manisha, P1 aGamit, Nehal, H uhttps://www.phcogres.com/article/2012/4/1/1041030974-849091040