02649nas a2200265 4500008004100000245011400041210006900155260001800224300001000242490000600252520179800258653003102056653001902087653002502106653001602131653002402147653002802171100002302199700002302222700001802245700001702263700001902280700001702299856006702316 2012 eng d00aAntidepressant-like Effects of Young Green Barley Leaf (Hordeum vulgare L.) in the Mouse Forced Swimming Test0 aAntidepressantlike Effects of Young Green Barley Leaf Hordeum vu cdecember,2011 a22-260 v43 a

Background: Young green barley leaf is one of the richest sources of antioxidants and has been widely consumed for health management in Japan. In this study, we examined whether oral administration of young green barley leaf has an antidepressant effect on the forced swimming test in mice. Materials and Methods: Mice were individually forced to swim in an open cylindrical container, one hour after oral administration of young green barley leaf (400 or 1000 mg / kg) or imipramine (100 mg / kg). Expression of mRNA for nerve growth factor (NGF), brain-derived neurotrophic factor, and glucocorticoid receptor in the brain was analyzed using real-time quantitative polymerase chain reaction (PCR). Results: There was a significant antidepressant-like effect in the forced swimming test; both 400 and 1000 mg / kg young green barley leaves, as well as the positive control imipramine (100 mg / kg), reduced the immobility duration compared to the vehicle group. The expression of mRNA for NGF detected in the hippocampus immediately after the last swimming test was higher than that in the non-swimming group (Nil). Oral administration of imipramine suppressed this increase to the level of the Nil group. Young green barley leaf (400 and 1000 mg / kg) also showed a moderate decrease in the expression of mRNA for NGF, in a dose-dependent manner. Conclusion: Oral administration of young green barley leaf is able to produce an antidepressant-like effect in the forced swimming test. Consequently it is possible that the antidepressant-like effects of the young green barley leaf are, at least in part, mediated by an inhibition of the increase in the hippocampus levels of NGF.

10aAntidepressant-like effect10aCorticosterone10aForced swimming test10aHippocampus10aNerve growth factor10aYoung green barley leaf1 aYamaura, Katsunori1 aNakayama, Noriyuki1 aShimada, Maki1 aBi, Yuanyuan1 aFukata, Hideki1 aUeno, Koichi uhttps://www.phcogres.com/article/2012/4/1/1041030974-849091030