02532nas a2200169 4500008004100000245008300041210006900124260001300193300001200206490000600218520197300224100002202197700002502219700002702244700002302271856006802294 2013 eng d00aProtective Effect of Juglans Nigra on Sodium Arsenite-induced Toxicity in Rats0 aProtective Effect of Juglans Nigra on Sodium Arseniteinduced Tox cMay 2013 a183-1880 v53 a

Background: Consumption of arsenic contaminated water has been implicated in metalloid-induced carcinogenesis. Dietary intake of certain plant products with chemoprotective properties may protect against the onset of diseases and promote maintenance of health. Objectives: We investigated the outcome of black walnut Juglans nigra (JN) consumption on sodium arsenite (SA)-induced toxicity in rats. Materials and Methods: Wister albino rats were treated as follows: Control, SA only (positive control) (2.5 mg/kg body weight), JN only (100 mg/kg weight), and JN+SA coadministered. After 5 weeks animals were sacrificed whole blood, femur, liver and testis harvested were assessed for hepatic transaminases and clastogenicity. Histology of the liver, sperm morphology and quality were also assessed. Data were analyzed (ANOVA) and expressed as means ±SD. Results: SA treatment elevated hepatic transaminases level in serum (P < 0.05), induced histological changes in liver: fibroplasia and periportal hepatocytes infiltration by mononuclear cells. These changes were ameliorated by JN (P < 0.05) coadministration. SA induced micronuclei formation (P < 0.05). Again JN decreased (P < 0.05) micronuclei formation by 50%. Sperm count and motility decreased (P < 0.05) in all groups compared to control. Conclusion: JN showed no protection against arsenite effect on sperm quality. Hepatoprotective and anticlastogenic effects were apparent suggesting a chemopreventive potential active against arsenite genotoxicity and chromosomal instability which have implication for metalloid-induced carcinogenesis

1 aOwumi, Solomon, E1 aOdunola, Oyeronke, A1 aGbadegesin, Michael, A1 aNulah, Kathleen, L uhttps://www.phcogres.com/article/2013/5/3/1041030974-8490112425