01875nas a2200217 4500008004100000245010200041210006900143260001300212300001200225490000600237520115900243653001501402653001901417653001701436653001801453100003101471700003101502700002701533700002901560856006801589 2013 eng d00aAnti-ulcer and Ulcer Healing Potentials of Musa Sapientum Peel Extract in the Laboratory Rodents0 aAntiulcer and Ulcer Healing Potentials of Musa Sapientum Peel Ex cMay 2013 a173-1780 v53 a

Background: This study investigated the anti-ulcer and ulcer healing potentials of the methanol extract of Musa sapientum peel in the laboratory rats. Materials and Methods: Methanol extract of the peels on Musa sapientum (MEMS) was evaluated for its anti-ulcer using alcohol-induced, aspirin-induced, and pyloric ligation-induced models, and for its ulcer healing employing acetic acid-induced ulcer models in rats. Results: The findings from this experiment showed that MEMS (50, 100 and 200 mg/kg, b.w.) anti-ulcer and ulcer healing activity (P ≤ 0.05) is dose-dependent. Also, MEMS exhibited healing of the ulcer base in all the treated groups when compared with the control group. Conclusion: The outcomes of this experiment revealed that the anti-ulcer effect of MEMS may be due to its anti-secretory and cyto-protective activity. The healing of the ulcer base might not be unconnected with basic fibroblast growth factors responsible for epithelial regeneration.

10aAnti-ulcer10aMusa sapientum10aPeptic Ulcer10aUlcer Healing1 aOnasanwo, Samuel, Adetunji1 aEmikpe, Benjamin, Obukowho1 aAjah, Austin, Azubuike1 aElufioye, Taiwo, Olayemi uhttps://www.phcogres.com/article/2013/5/3/1041030974-8490112423