01743nas a2200181 4500008004100000245009000041210006900131260001300200300001200213490000600225520112300231653001301354653004701367653002701414100002101441700003101462856006801493 2013 eng d00aBronchodilatory Effect of Ethanolic Extract of the Leaves of Nyctanthes Arbortristis,0 aBronchodilatory Effect of Ethanolic Extract of the Leaves of Nyc cMay 2013 a169-1720 v53 a

Background: Nyctanthes arbortristis has been used in traditional medicine for the treatment of asthma and cough. Aim: In this study, bronchodilatory effect of ethanolic extract of the N. arbortristis was investigated under in vitro conditions. The concentration-response curve of the tracheal smooth muscle (TSM) to histamine was recorded in presence or absence of ethanolic extract and Nω-nitro-l-arginine methyl ester (L-NAME). Dose-response effect of ethanolic extract on pre-constricted tissues was investigated. The ethanolic extract inhibited the histamine-induced maximum contractile responses of TSM ( P < 0.001). Ethanolic extract also cause dose-dependent relaxation of TSM. These effects were reversed by L-NAME. Phytochemical analysis showed the presence of typical plant constituents. These results suggest the possible use of extract of the leaves of N. arbortristis as a bronchodilator in therapeutic treatment of asthma.

10aa0 sthma10aEthanolic Eextract Nyctanthes Arbortristis10aTracheal Smooth Muscle1 aSopi, Ramadan, B1 aKhan, Muhammad, Feroz Haya uhttps://www.phcogres.com/article/2013/5/3/1041030974-8490112422