02401nas a2200217 4500008004100000245017400041210006900215260001500284300001000299490000600309520166000315653001801975653001601993653001602009653001802025653001402043653001302057100002202070700002402092856006702116 2012 eng d00aAntioxidant and Antibacterial Activities of the Leaf Essential Oil and its Constituents Furanodienone and Curzerenone from Lindera pulcherrima (Nees.) Benth. ex hook. f.0 aAntioxidant and Antibacterial Activities of the Leaf Essential O capril,2012 a80-840 v43 a

Background: Lindera pulcherrima (Nees.) Benth. ex Hook. f. (Family: Lauraceae), an evergreen shrub, is an important medicinal plant distributed in temperate Himalayan regions. The leaves and bark are used as spice in cold, fever, and cough. Materials and Methods: In this study, the terpenoid composition, antioxidant, and antibacterial activities of the leaf essential oil and its major constituents are being analyzed. Conclusion: The in vitro antioxidant activity showed a potent free radical scavenging activity for the essential oil as evidenced by a low IC 50 value for DPPH radical followed by furanodienone (0.087 ± 0.03 and 1.164 ± 0.58 mg/ml respectively) and the inhibition of lipid peroxidation for the oil and furanodienone also followed the same order (IC 50 0.74 ± 0.13 and 2.12 ± 0.49 mg/ml, respectively). The oil and the constituents were also tested against three Gram negative (Escherichia coli, Salmonella enterica enterica, and (Pasturella multocida) and one Gram positive (Staphylococcus aureus) bacteria. The essential oil was effective against S. aureus (IZ = 19.0 ± 0.34; MIC 3.90 μl/ml) while furanodienone showed potent activity against E. coli and S. enterica enterica (IZ = 18.0 ± 0.14 and 16.0 ± 0.10 respectively). On the other hand, curzerenone was found to be slightly effective against E. coli (IZ = 10.8 ± 0.52). The MIC value of the essential oil was least against S. aureus (MIC = 3.90 μl/ml) and that of furanodienone against E. coli (MIC = 3.90 μl/m

10aAntibacterial10aAntioxidant10aCurzerenone10aFuranodienone10aLauraceae10aLindera.1 aJoshi, Subhash, C1 aMathela, Chandra, S uhttps://www.phcogres.com/article/2012/4/2/1041030974-849094721