01999nas a2200265 4500008004100000245011200041210006900153260001300222300001200235490000600247520116200253653002501415653001401440653002201454653001601476653001401492653001401506653001401520653002601534100002501560700003101585700002401616700002501640856006801665 2013 eng d00aEvaluation of Marine Brown Algae Sargassum ilicifolium Extract for Analgesic and Anti-inflammatory Activity0 aEvaluation of Marine Brown Algae Sargassum ilicifolium Extract f cMay 2013 a146-1490 v53 a
Background : The methanolic extract of Sargassum ilicifolium (Pheophyceae) was used to evaluate its analgesic and anti-inflammatory activity in the present study. Materials and Methods: Analgesic activity was tested using Acetic acid writhing method and Eddy hot plate method in Male albino mice and Wister rats respectively at a dose level of 1, 10, 50, 100mg/kg p.o. At the same dose, its anti-inflammatory activity was also tested using Carrageenan induced rat paw edema method Result Acetic acid writhing test and Eddy's hot plate episodes were significantly and dose dependently reduced. Carrageenan (a standard inflammatory agent) induced paw edema in rats was significantly reduced after intraperitonal administration of methanolic extract. Results: showed dose dependant significant activity in comparison with standard and control. Conclusion: Methanolic extracts of the brown seaweeds Sargassum ilicifolium have potent analgesic and anti-inflammatory activity at moderate doses.
10aAcetic acid Writhing10aAnalgesic10aAnti-inflammatory10aCarrageenan10aGranuloma10aHot Plate10aPaw edema10aSargassum Ilicifolium1 aSimpi, Chandraraj, C1 aNagathan, Channabasappa, V1 aKarajgi, Santosh, R1 aKalyane, Navanath, V uhttps://www.phcogres.com/article/2013/5/3/1041030974-8490112413