02664nas a2200193 4500008004100000245010100041210006900142260001600211300001300227490000600240520203900246653001402285653003302299653001802332100001902350700001402369700001902383856006802402 2013 eng d00aAnti-arthritic Activity of Ethanolic Extract of Tridax Procumbens (Linn.) in Sprague Dawley Rats0 aAntiarthritic Activity of Ethanolic Extract of Tridax Procumbens cApril 2013 a 113-1170 v53 a

Objective: To determine the anti-arthritic effect of whole plant ethanolic extract of Tridax procumbens (Asteraceae) in female Sprague Dawley (SD) rats using the Freund's Complete Adjuvant (FCA) model. Materials and Methods: The plant was collected from different regions of Madurai District, Tamil Nadu, and the phytoconstituents were identified through chemical tests. Ethanol (95%) was used to obtain the whole plant extraction through Soxhlet extractor. Female SD rats were used for anti-arthritic screening. Arthritis was induced using FCA, and the anti-arthritic effect of the ethanolic extract of T. procumbens was studied at doses of 250 and 500 mg/kg. The effects were compared with those of indomethacin (10 mg/kg). At the end of the study, the liver enzyme levels were determined and a radiological examination was carried out. Result: The preliminary phytochemical analysis of the ethanolic extract of T. procumbens indicated the presence of alkaloids, tannins, flavonoids and saponins. T. procumbens at 250 and 500 mg/kg significantly inhibited the FCA-induced arthritis in the rats. This was manifested by as a decrease in the paw volume. The arthritic control animals exhibited a significant decrease in body weight compared with control animals without arthritis. T. procumbens animals showed dose dependent reduction in decrees in body weight and arthritis. At the same time, T. procumbens significantly altered the biochemical and haematological changes induced by FCA ( P < 0.05). The anti-arthritic effect of T. procumbens was comparable with that of indomethacin. Conclusion: The whole plant extract of T. procumbens showed significant anti-arthritic activity against FCA-induced arthritis in female SD rats.

10aArthritis10aFreund′s Complete Adjuvant10aT. Procumbens1 aPetchi, Ramesh1 aVijaya, C1 aParasuraman, S uhttps://www.phcogres.com/article/2013/5/2/1041030974-8490110541