02377nas a2200265 4500008004100000245011600041210006900157260001400226300001200240490000600252520148300258653002001741653002701761653002201788653001901810100003001829700002701859700002901886700002501915700002701940700002501967700002401992700002802016856006702044 2012 eng d00aChemical Composition, Antibacterial and Antifungal Activities of Essential Oil from Cordia Verbenacea DC Leaves0 aChemical Composition Antibacterial and Antifungal Activities of  cJuly,2012 a161-1650 v43 a

Background: Cordia verbenacea is a Brazilian coastal shrub popularly known as “erva baleeira”. The essential oil from fresh leaves was obtained by hydrodistillation and analyzed by CG/MS. The main components were identified as β-caryophyllene (25.4%), bicyclogermacrene (11.3%), δ-cadinene (9.%) and α-pinene (9.5%). In this study, the antimicrobial activity of Cordia verbenacea was evaluated. Materials and Methods: The minimal inhibitory concentration (MIC) of the essential oil was obtained using the broth microdilution assay (from 512 to 8 μg/ml). Results: The results showed that the essential oil presented fungistatic activity against Candida albicans and Candida krusei and antibacterial activity against Gram-positive strains (Staphylococcus aureus and Bacillus cereus) and against multiresistant Gram-negative (Escherichia coli 27), in all tests the MIC was 64 µg/ml. When the essential oil was associated to aminoglycosides (subinhibitory concentrations, MIC/8), a synergic and antagonic activity was verified. The synergic effect was observed to the amikacin association (MIC reduction from 256 mlto 64 µg/ml) in all strains tested. Conclusion: The essential oil of Cordia verbenacea influences the activity of antibiotics and may be used as an adjuvant in antibiotic therapy against respiratory tract bacterial pathogens.

10aAminoglycosides10aAntimicrobial activity10aCordia verbenacea10aEssential oil.1 aRodrigues, Fabiola, F. G.1 aOliveira, Liana, G. S.1 aRodrigues, Fábio, F. G.1 aSaraiva, Manuele, E.1 aAlmeida, Sheyla, C. X.1 aCabral, Mario, E. S.1 aCampos, Adriana, R.1 aCosta, Jose, Galberto M uhttps://www.phcogres.com/article/2012/4/3/1041030974-849099080