02489nas a2200253 4500008004100000245011500041210006900156260001400225300001000239490000600249520162500255653002101880653002501901653001501926653002301941653001301964100003801977700003002015700003002045700002902075700003202104700003202136856006702168 2011 eng d00aLiver Protective Activity of a Hydroethanolic Extract of Arrabidaea chica (Humb. and Bonpl.) B. Verl. (pariri)0 aLiver Protective Activity of a Hydroethanolic Extract of Arrabid cJune 2011 a79-840 v33 a

Background: Folk medicine uses preparations of Arrabidaea chica (pariri) leaves to treat various liver pathologies. We evaluated the effects of the hydroethanolic extract of these leaves (CHEE) on an in vivo model of liver intoxication. Materials and Methods: Different groups of rats were treated orally for 7 days with CHEE at doses of 300, 500 or 600 mg/kg or silymarin at 35 mg/kg. The control group received only 0.5 ml of distilled water. After 7 days of treatment, both the groups received CCl 4 , and activities of glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT) and bilirubin level were assessed. The ability of CHEE to suppress hepatic injury triggered by CCl 4 was evaluated based on suppression (%) of activities of GOT, GPT and bilirubin levels. Results: The chromatograms of the CHEE obtained at 330 and 400 nm show features of two main classes of secondary metabolites: quinones and flavonoids. The administration of 300, 500 or 600 mg/kg of CHEE resulted in the reduction of GPT levels by 85.34%, 88.59% and 93.72%, respectively. The suppression of GOT levels was 56.86%, 65.27% and 68.95%, respectively, and that of plasma bilirubin was 83.81%, 83.12% and 84.14%, respectively. These results demonstrate the protective character of CHEE and its ability to maintain the functional integrity of hepatic cells. Conclusions: The results obtained are possibly due to the presence of quinones and flavonoids in A. chica CHEE, both detected using high performance liquid chromatography

10aArrabidaea chica10aCarbon tetrachloride10aFlavonoids10aHepatic protection10aQuinones1 ade Medeiros, Benedito, Junior Lim1 aCosta, Kelém, dos Santos1 aRibeiro, Jeane, Francisca1 aSilva, José, Otavio Car1 aBarbosa, Wagner, Luiz Ramos1 aCarvalho, José, Carlos Tav uhttps://www.phcogres.com/article/2011/3/2/1041030974-849081954