02038nas a2200229 4500008004100000245012700041210006900168260001400237300001200251490000600263520128200269653002301551653002301574653001301597653002301610100001301633700001601646700002301662700002301685700003101708856006901739 2015 eng d00aEvaluation of anxiolytic activity of aqueous extract of Coriandrum sativum Linn. in mice: A preliminary experimental study0 aEvaluation of anxiolytic activity of aqueous extract of Coriandr cJune 2015 as47-s510 v73 a

Objectives: To evaluate the anxiolytic effect of Coriandrum sativum (CS) aqueous extract in mice. To compare the antianxiety activity of CS against standard drug diazepam (3 mg/kg). Materials and Methods: After obtaining Institutional Animal Ethics Committee approval, Swiss albino mice (18-25 g) of either sex were randomly divided into five groups of six animals each. Dried powder of CS leaves was boiled with distilled water, cooled, filtered, placed on a hotplate for complete evaporation, finally weighed and stored. The control group, test group, and standard drugs group received saline, CS extract (50, 100, and 200 mg/kg), diazepam (3 mg/kg), respectively, by oral feeding. The antianxiety effect was assessed by elevated plus maze (EPM) in mice. Results: In EPM, it implied that CS 50 mg/kg (Group III), 100 mg/kg (Group IV), and 200 mg/kg (Group V) significantly (P < 0.001) increases the number of entries in open arms compared to control. The time spent in open arms also increased in all the doses of CS extract significantly. Conclusion: The current study demonstrates statistically significant dose-dependent antianxiety activity of CS leaves.

10aAntianxiety effect10aCoriandrum sativum10aDiazepam10aElevated plus maze1 aLatha, K1 aRammohan, B1 aSunanda, B., P. V.1 aMaheswari, MS, Uma1 aMohan, Surapaneni, Krishna uhttps://www.phcogres.com/article/2015/7/5s/1041030974-8490157996