02247nas a2200241 4500008004100000245010600041210007100147260001700218300001200235490000600247520146700253653003001720653001601750653002601766653001201792100002101804700001901825700002801844700002301872700001801895700002401913856006801937 2015 eng d00aAlpha‑amylase inhibitory activity and sterol composition of the marine algae, Sargassum glaucescens0 aAlpha‑amylase inhibitory activity and sterol composition of the  cOctober 2015 a314-3210 v73 a

Background: Sargassum species (phaeophyceae) are economically important brown algae in southern parts of Iran. Sargassum is mainly harvested as a row material in alginate production industries and is a source of plant foods or plant bio‑stimulants even a component of animal foods. Objectives: In this study, Sargassum glaucescens, collected from the seashore of Chabahar, was employed for phytochemical and biological evaluations. Materials and Methods: For that purpose, the dried algae was extracted by methanol and subjected to different chromatographic separation methods. Results: Six sterols, fucosterol (1), 24(S)‑hydroxy‑24‑vinylcholesterol (2), 24(R)‑hydroxy‑24‑vinylcholesterol (3), stigmasterol (4), β‑sitosterol (5) and cholesterol (6) were identified by spectroscopic methods including 1H‑NMR, 13C‑NMR and mass spectroscopy. In vitro alpha‑amylase inhibitory test was performed on the methanolic extract and the results revealed a potent inhibition (IC50 = 8.9 ± 2.4 mg/mL) of the enzyme compared to acarbose as a positive control. Conclusion: Various biological activities and distribution of sterols in Sargassum genus have been critically reviewed here. The results concluded that these algae are a good candidate for further anti‑diabetic investigations in animals and human.

10aAlpha‑amylase inhibitor10aBrown algae10aSargassum glaucescens10aSterol.1 aPayghami, Nasrin1 aJamili, Shahla1 aRustaiyan, Abdolhossein1 aSaeidnia, Soodabeh1 aNikan, Marjan1 aGohari, Ahmad, Reza uhttps://www.phcogres.com/article/2015/7/4/1041030974-8490167893