02389nas a2200265 4500008004100000245010500041210006900146260001800215300001200233490000600245520156400251653002201815653001801837653001601855653002301871653001001894100001701904700001601921700002101937700003101958700002201989700002102011700002302032856006802055 2016 eng d00aAntimicrobial, Anti-inflammatory and Antioxidant Activities of Jatropha multifida L. (Euphorbiaceae)0 aAntimicrobial Antiinflammatory and Antioxidant Activities of Jat cFebruary 2016 a142-1460 v83 a

Background: Jatropha multifida is used in Togolease folk medicine for the healing of chronic wounds. Objective: This study aims to investigate antibacterial, anti-inflammatory and antioxidant activities of the leaves ethanolic extract. Materials and Methods: The antimicrobial activity was assayed by National Committee for Clinical Laboratory Standards broth microdilution method on strains of Staphylococcus aureus and Pseudomoas aeruginosa isolated from wounds, whereas the anti-inflammatory activity was performed by carrageenan and histamine induced paw edema method in rat modele. The 2, 2-diphenyl- 1picrylhydrazyl (DPPH) free radical scavenging and ferric reducing antioxidant power (FRAP) were used for the antioxidant activity. Results: The antibacterial assay showed an in vitro growth inhibition of P. aeruginosa and S. aureus in dose-dependent manner, with minimum inhibitory concentration values ranging from 2.5 to 3.12 mg/mL for S. aureus and from 6.25 to 12.5 mg/mL for P. aeruginosa. The maximum paw anti-inflammatory effect occurred after 3 and 5 h administration of histamine and carrageenan, respectively. The DPPH radical scavenging and the FRAP assays yielded weak antioxidant activity. Conclusion: J. multifida possesses antibacterial and anti-inflammatory activities that could justify the use of the plant for the treatment of wounds in the folk medicine. Key words:

10aAnti-inflammatory10aAntibacterial10aAntioxidant10aJatropha multifida10awound1 aAnani, Kokou1 aAdjrah, Yao1 aAméyapoh, Yaovi1 aKarou, Simplice, Damintoti1 aAgbonon, Amegnona1 ade Souza, Comlan1 aGbeassor, Messanvi uhttps://www.phcogres.com/article/2016/8/2/1041030974-8490172657