01927nas a2200205 4500008004100000245010300041210006900144260001400213300001200227490000600239520127400245653001801519653002101537653002101558653002201579653001601601100001501617700002101632856006801653 2015 eng d00aIn vivo anti-inflammatory and Antiarthritic Activities of Aqueous Extracts from Thymelaea Hirsuta,0 aIn vivo antiinflammatory and Antiarthritic Activities of Aqueous cJune 2015 a213-2160 v73 a

Background: The aerial parts of Thymelaea hirsuta (TH) are used as a decoction in the treatment of different pathologies in folk medicine in Morocco. Objective: The aqueous extracts were evaluated for its anti-inflammatory activity and in inhibition of adjuvant induction arthritis in male Wistar rats. Materials and Methods: The anti-inflammatory activity was carried out using carrageenan-induced rat paw edema model, and the antiarthritic activity was carried out using complete Freund's adjuvant-induced arthritis model. Results: The plant extract (500 mg/kg body weight) exhibited significant activity in acute inflammation produced 60% of inhibition after 4 h as compared with that of the standard anti-inflammatory drug, the diclofenac (100 mg/kg) which showed 40% of inhibition. In arthritis model, the extract produced 85% inhibition after 18 days when compared with the diclofenac (10 mg/kg; 72%). Conclusion: These results indicate that the aqueous extract of TH had an anti-inflammatory activity and inhibited the induction of adjuvant arthritis in male Wistar rats.

10aAntiarthritis10aAntiinflammation10aMedicinal plants10aThymelaea hirsuta10aWistar rats1 aAzza, Zora1 aOudghiri, Mounia uhttps://www.phcogres.com/article/2015/7/2/1041030974-8490150510