01756nas a2200205 4500008004100000245010000041210006900141260001400210300001200224490000600236520106500242653003001307653002101337653002601358653003301384653002801417100002401445700001301469856006801482 2015 eng d00aReview of clinical studies of Polygonum multiflorum Thunb. and its isolated bioactive compounds0 aReview of clinical studies of Polygonum multiflorum Thunb and it cJune,2015 a225-2360 v73 a

Polygonum multiflorum Thunb. (PMT), officially listed in the Chinese Pharmacopoeia, is one of the most popular perennial Chinese traditional medicines known as He shou wu in China and East Asia, and as Fo‑ti in North America. Mounting pharmacological studies have stressed out its key benefice for the treatment of various diseases and medical conditions such as liver injury, cancer, diabetes, alopecia, atherosclerosis, and neurodegenerative diseases as well. International databases such as PubMed/Medline, Science citation Index and Google Scholar were searched for clinical studies recently published on P. multiflorum. Various clinical studies published articles were retrieved, providing information relevant to pharmacokinetics‑pharmacodynamics analysis, sleep disorders, dyslipidemia treatment, and neurodegenerative diseases. This review is an effort to update the clinical picture of investigations ever carried on PMT and/or its isolated bio‑compounds and to enlighten its therapeutic assessment.

10aClinical pharmacokinetics10aClinical studies10aHerbal hepatotoxicity10aPolygonum multiflorum Thunb.10aTherapeutic assessment.1 aBounda, Guy‑Armel1 aYU, Feng uhttps://www.phcogres.com/article/2015/7/3/1041030974-8490157957