02398nas a2200265 4500008004100000245013700041210006900178260001900247300001200266490000600278520153300284653001801817653002401835653001501859653002501874653002001899653002501919100002101944700001901965700002101984700002602005700002002031700002002051856006102071 2017 eng d00aEffect of the Administration of Solanum nigrum Fruit on Prevention of Diabetic Nephropathy in Streptozotocin‑induced Diabetic Rats0 aEffect of the Administration of Solanum nigrum Fruit on Preventi cNovember 2017 a325-3320 v93 a

Background: Our previous study showed antidiabetic effect of aqueous extract of Solanum nigrum Linn fruit (SNE). Objective: This study was designed to explore the antidiabetic and nephroprotective effects of SNE in diabetic rats. Materials and Methods: Animals were divided into nine groups to undergo two experiment protocols: Two groups served as nondiabetic controls (NDCs), while the other groups had diabetes induced with a single injection of streptozotocin. SNE‑treated diabetic (D‑SNE) and SNE‑treated controls (NDC‑SNE) received 1 g/L of SNE added to the drinking water and insulin‑treated diabetic (D‑I) for 8 weeks. Furthermore, there were four groups (D‑SNE, NDC‑SNE, D‑I, D) in the second protocol to examine diabetic nephropathy (DN) for 16 weeks. Blood urea nitrogen (BUN), creatinine (Cr) magnesium, nitric oxide (NO), and malondialdehyde (MDA) levels were measured. Both kidneys were isolated to measure MDA, NO levels, and renal damage. Results: SNE could decrease blood glucose level in diabetic rats. In addition, SNE was more effective than insulin in controlling blood glucose. SNE could decrease BUN, Cr levels, and kidney weight and damage after 8 and 16 weeks of administration. Plasma and kidney levels of NO and MDA also decreased. Conclusion: Our results support the hypothesis that SNE could play a role in the management of diabetes and the prevention of DN.

10aBlood glucose10aBlood urea nitrogen10aCreatinine10aDiabetic nephropathy10aMalondialdehyde10aSolanum nigrum fruit1 aAzarkish, Fariba1 aHashemi, Kobra1 aTalebi, Ardashir1 aKamalinejad, Mohammad1 aSoltani, Nepton1 aPouladian, Nima uhttps://www.phcogres.com/article/2017/9/4/104103prpr4717