02060nas a2200205 4500008004100000245006500041210006500106260001400171300001200185490000600197520142000203653001801623653001601641653002801657653003101685100002601716700001801742700002601760856006801786 2015 eng d00aSerum Total Aantioxidant Capacity in Oral Carcinoma Patients0 aSerum Total Aantioxidant Capacity in Oral Carcinoma Patients cJune 2015 a184-1870 v73 a

Context: Oxidative stress is a major determinant in carcinogenesis and serum total antioxidant capacity (TAC) indirectly reflects the level of oxidative stress. Although oral cancer is the third most frequent cancer in Indian population, there are no standard noninvasive marker for early detection and monitoring therapeutic response in oral cancer patients. Aims: This study was carried out to investigate implications of serum TAC in oral cancer by evaluating pre‑ and post‑operative levels in oral cancer patients. Settings and Designs: It was a prospective single blinded study. Subjects and Methods: Serum TAC was measured using ferric‑reducing antioxidant power assay. Pre‑ and post‑operative values were estimated and compared in 30 oral cancer patients who underwent surgery. Statistical Analysis Used: Paired t-test was used to compare pre‑ and post‑operative values. Results: Compared to the normal value, both pre‑ and post‑operative serum TAC were significantly low in oral cancer patients. However, there was no statistically significant difference between pre‑ and postoperative levels. Conclusions: In this study, low mean serum TAC was detected in oral cancer patients. However, its diagnostic and prognostic significance in oral cancer needs further investigation.

10aCancer Marker10aOral cancer10aSquamous Cell Carcinoma10aTotal Antioxidant Capacity1 aShetty, K., S. Rathan1 aKali, Arunava1 aShetty, K., S. Rachan uhttps://www.phcogres.com/article/2015/7/2/1041030974-8490150513