02153nas a2200229 4500008004100000245010800041210007100149260001800220300001000238490000600248520142200254653001601676653002401692653000901716653001601725653001001741653001101751653002301762100003301785700003701818856006801855 2016 eng d00aAnti‑Lipoxygenase Activity of Leaf Gall Extracts of Terminalia chebula (Gaertn.) Retz. (Combretaceae)0 aAnti‑Lipoxygenase Activity of Leaf Gall Extracts of Terminalia c cDecember 2015 a78-820 v83 a

Lipoxygenase (LOX) inhibitors are the promising therapeutic target for treating a wide spectrum of inflammatory‑related diseases such as cancer, asthma, lymphoma, leukemia, and autoimmune disorders. In the present study, the photochemical constituents and the anti‑LOX potential of leaf galls of Terminalia chebula are evaluated to exemplify its further potential development as medicine. Extracts of T. chebula galls were tested for anti‑LOX activity using linoleic acid as substrate and lipoxidase as an enzyme and also the total content of polyphenols with phytochemical analysis of the extract were determined. The presence of highest total phenolic and flavonoid content of 141 ± 2.2 mg of gallic acid equivalent/g d.w and 125 ± 1.4 mg of quercetin equivalent/g d.w and maximal LOX inhibitory activity (52.67%) at 800 μg/mL concentrations were identified in the ethanolic extracts of leaf galls of T.chebula. The higher LOX inhibitory activity was positively correlated to the high content of total polyphenols/flavonoids. The results of this study confirm the folklore use of T. chebula leaves gall extracts as a natural anti‑inflammatory agent and justify its ethnobotanical use. Therefore, the results encourage the use of T. chebula leave gall extracts for medicinal health, functional food, and nutraceuticals applications.

10aAntioxidant10aAnti‑lipoxygenase10aDrug10aGallic acid10aGalls10aPlants10aTerminalia chebula1 aEshwarappa, Ravi, Shankara B1 aRamachandra, Yarappa, Lakshmikan uhttps://www.phcogres.com/article/2016/8/1/1041030974-8490171103