02558nas a2200265 4500008004100000245008600041210006900127260001800196300001000214490000600224520172000230653001301950653001401963653002601977653001302003653003102016653001902047100003402066700002002100700001802120700002402138700003102162700003102193856006802224 2015 eng d00aAcute oral toxicity studies of Swietenia macrophylla seeds in Sprague Dawley rats0 aAcute oral toxicity studies of Swietenia macrophylla seeds in Sp cDecember 2014 a38-440 v73 a

Background: Swietenia macrophylla King. (Meliaceae) seeds (SMS); commonly known as sky fruit and locally known in Malaysia as Tunjuk Langit; have been used in traditional Malay medicine for the treatment of diabetes and hypertension. The people eat only a tiny amount of raw seed, weighing not more than 5 mg. Aim: To evaluate the safety of Swietenia macrophylla seeds (SMS) at a single‑dose oral administration of 2 g/kg body weight (bw) in sprague dawley (SD) rats. Materials and Methods: Eight‑week old male and female SD rats were administered a single‑oral dose of 2g/kg bw. The rats’ general behavior, and toxic signs were observed throughout the 14‑day study period. The food and water intake by rats and their body weight were monitored during the study period. At the end of the study period, the relative weights of the organs (lung, liver, spleen, heart, kidney, testis, stomach); the hematological and biochemical parameters were measured; the architecture and histology of the organs (liver, kidney and lungs) were observed. Results: Oral administration of SMS to rats did not affect, either food or water intake; relative organ weight of vital organs; the hematological and biochemical parameters; did not show significant changes in the architecture and histology of vital organs. Overall, there were neither signs of toxicity nor deaths recorded during the study period. Conclusion: The rat dose of 2 g/kg bw is equivalent to the human dose of 325 mg/kg bw, which is well below the usual amount consumed by people, did not show any signs of toxicity in rats.

10aDiabetes10aSky fruit10aSwietenia macrophylla10aToxicity10aTraditional Malay medicine10aTunjuk langit.1 aBalijepalli, Madhu, Katyayani1 aSuppaiah, Velan1 aChin, An‑me1 aBuru, Ayuba, Sunday1 aSagineedu, Sreenivasa, Rao1 aPichika, Mallikarjuna, Rao uhttps://www.phcogres.com/article/2015/7/1/1041030974-8490147197