02808nas a2200265 4500008004100000245015200041210006900193260001800262300000800280490000600288520193500294653002702229653001602256653001202272653001802284653001502302653002102317100002602338700002402364700001802388700002102406700002802427700001902455856006802474 2016 eng d00aEffect of Beta vulgaris Linn. Leaves Extract on Anxiety‑ and Depressive‑like Behavior and Oxidative Stress in Mice after Acute Restraint Stress0 aEffect of Beta vulgaris Linn Leaves Extract on Anxiety and Depre cDecember 2015 a1-70 v83 a

Background: Stress plays a significant role in the pathogenesis of neuropsychiatric disorders such as anxiety and depression. Beta vulgaris is commonly known as “beet root” possessing antioxidant, anticancer, hepatoprotective, nephroprotective, wound healing, and anti‑inflammatory properties. Objective: To study the protective effect of Beta vulgaris Linn. ethanolic extract (BVEE) of leaves against acute restraint stress (ARS)‑induced anxiety‑ and depressive‑like behavior and oxidative stress in mice. Materials and Methods: Mice (n = 6) were pretreated with BVEE (100 and 200 mg/kg, p. o.) for 7 days and subjected to ARS for 6 h to induce behavioral and biochemical changes. Anxiety‑ and depressive‑like behavior were measured by using different behavioral paradigms such as open field test (OFT), elevated plus maze (EPM), forced swim test (FST), and tail suspension test (TST) 40 min postARS. Brain homogenate was used to analyze oxidative stress parameters, that is, malondialdehyde (MDA) and reduced glutathione (GSH) level. Results: BVEE pretreatment significantly (P < 0.05) reversed the ARS‑induced reduction in EPM parameters, that is, percentage entries and time spent in open arms and in OFT parameters, that is, line crossings, and rearings in mice. ARS‑induced increase in the immobility time in FST and TST was attenuated significantly (P < 0.05) by BVEE pretreatment at both the dosage. An increase in MDA and depletion of GSH level postARS was prevented significantly (P < 0.05) with BVEE pretreatment at both the dosage (100 and 200 mg/kg). Conclusion: BVEE exhibits anxiolytic and antidepressant activity in stressed mice along with good antioxidant property suggesting its therapeutic potential in the treatment of stress‑related psychiatric disorders.

10aAcute restraint stress10aAntioxidant10aAnxiety10aBeta vulgaris10aDepression10aOxidative stress1 aSulakhiya, Kunjbihari1 aPatel, Vikas, Kumar1 aSaxena, Rahul1 aDashore, Jagrati1 aSrivastava, Amit, Kumar1 aRathore, Manoj uhttps://www.phcogres.com/article/2016/8/1/1041030974-8490171100