02509nas a2200205 4500008004100000245013400041210006900175260001500244300001200259490000600271520181600277653001902093653001602112653002702128100002702155700001902182700002102201700001902222856006202241 2017 eng d00aPotential Roles of Kleinhovia hospita L. Leaf Extract in Reducing Doxorubicin Acute Hepatic, Cardiac and Renal Toxicities in Rats0 aPotential Roles of Kleinhovia hospita L Leaf Extract in Reducing cApril 2017 a168-1730 v93 a

Background: Doxorubicin (DOX) is a potent chemotherapy agent; however, its use may lead to cardiac, hepatic, and renal dysfunction. Kleinhovia hospita L extract contains antioxidant compounds that have been shown to reduce chemical-induced hepatotoxicity. Objectives: This study aimed to examine the protective effects of Kleinhovia sp. extract to reduce DOX acute toxicities. Materials and Methods: Thirty male rats were assigned to the following groups: Group I as controls, Group II was given DOX i.p. injection (25 mg/kg); Groups III, IV, and V were treated with Kleinhovia sp. extract 100, 250, and 500 mg/kg orally for 5 days, respectively, prior to DOX i.p. injection. After 24 h, blood and organs were analyzed for biomarker levels and histopathological changes. Results: DOX treatment in Group II significantly increased creatine kinase-MB (CK-MB), aspartate transaminase (AST), alanine transaminase (ALT), and urea levels compared to controls. Kleinhovia sp. extract at any given dose significantly improved ALT and AST; yet, CK-MB levels only reduced with 250 mg/kg dose (Group IV). Urea and creatinine levels in Kleinhovia sp. groups were also lower compared to DOX-treated rats, but it was not significant. Histopathological analysis showed improved liver, heart, and renal tissue structures in Kleinhovia sp-treated rats, especially at higher doses. Conclusion: Kleinhovia sp. extract at any dose given protected the rats from liver toxicity, but only at dose 250 mg/kg reduced cardiac toxicity. Although renal biomarkers were insignificantly lower, renal architecture was improved with Kleinhovia sp. treatment.

10aAcute toxicity10aDoxorubicin10aKleinhovia sp. extract1 aDjabir, Yulia, Yusrini1 aArsyad, Aryadi1 aSartini, Sartini1 aLallo, Subehan uhttps://www.phcogres.com/article/2017/9/2/104103prpr12916