02322nas a2200241 4500008004100000245011600041210007100157260001800228300001000246490000600256520154600262653002501808653002101833653001501854653001701869100001701886700002601903700001901929700002801948700001801976700001801994856006802012 2017 eng d00aEvaluation of Cholesterol‑lowering Activity of Standardized Extract of Mangifera indica in Albino Wistar Rats0 aEvaluation of Cholesterol‑lowering Activity of Standardized Extr cFebruary 2017 a21-260 v93 a

Introduction: Cholesterol lowering activity of Mangifera indica L. has been determined by earlier researchers and kernel, leaf and bark have shown significant activity. However, the specific cholesterol lowering activity of leaf methanol extract has not been determined. Materials and Methods: The present study involved evaluation of cholesterol lowering potential of methanol extract of M. indica leaves using high cholesterol diet model in albino Wistar rats. The acute oral toxicity at a dose of 5000 mg/ kg body weight was also determined in female albino Wistar rats. Phytoconstituents Iriflophenone 3-C-β-D-glucoside and mangiferin were quantified in methanol extracts of different varieties of mango leaves using high performance liquid chromatography. Results and Discussion: Significant cholesterol lowering activity was observed with methanol extract of M. indica leaves, at dose of 90 mg/kg body weight in rats and it was also found to be safe at dose of 5000 mg/kg rat body. Iriflophenone 3-C-β-D-glucoside and mangiferin were found to be in the range of 1.2 to 2.8% w/w and 3.9 to 4.6% w/w, respectively which along with 3 β taraxerol and other sterols could be contributing to the cholesterol lowering activity of mango leaves extract. Conclusions: The phytosterols rich extract of Mangifera indica leaves is a good source of nutraceutical ingredient that have the potential to lower serum cholesterol levels.

10aHypercholesterolemia10aMangifera indica10aMangiferin10aMango leaves1 aGururaja, GM1 aMundkinajeddu, Deepak1 aKumar, Senthil1 aDethe, Shekhar, Michael1 aAllan, Joshua1 aAgarwal, Amit uhttps://www.phcogres.com/article/2017/9/1/1041030974-8490199770