03060nas a2200289 4500008004100000245011000041210006900151260001500220300001200235490000700247520210700254653001202361653001102373653002402384653001902408653002202427100003002449700002902479700002902508700002602537700002402563700003002587700003002617700003102647700003002678856006202708 2019 eng d00aAnatomical and Phytochemical Characterization of Physalis angulata L.: A Plant with Therapeutic Potential0 aAnatomical and Phytochemical Characterization of Physalis angula cApril 2019 a171-1770 v113 a

Background: Physalis angulata L. is widely used in folk medicine. Secondary metabolites with pharmacological potential, including physalins that exhibit anti‑inflammatory/immunomodulatory and antiparasitic activities, have been identified in this specie. To date, few studies have investigated storage sites for secondary metabolites in P. angulata. Objective: The objective of the study is to characterize the anatomical structures and determine the phytochemical composition of the vegetative organs of P. angulata. Materials and Methods: Electron and conventional optical microscopy was used for the anatomical characterization of P angulata organs (leaves, roots, stems, and fruits). Methanolic extracts from leaves, roots, stems, and fruits were chemically characterized for the presence of steroids, terpenoids, tannins, alkaloids, saponins, flavonoids, anthraquinones, coumarins, and phenolic compounds. Phenolic compounds, flavonoid contents, and antioxidant capacity of these extracts were determined by 2,2‑diphenyl‑1‑picrylhydrazyl‑free radical scavenging activity. Results: Abaxial leaf stomata were more abundant than the adaxial stomata. Trichomes were more abundant along veins in the petioles and stems, beyond the margin in the sepals and petals, and dispersed in the ovary. Steroids and terpenoids were present in leaves, stems, and fruits of P. angulata. Saponins were exclusive to fruits. Phytochemical screening did not detect flavonoids, anthraquinones, and alkaloids in all tested plant parts. The highest antioxidant capacities were identified in leaf and fruit extracts, possibly due to the presence of phenolic compounds in these organs. Conclusion: This study describes anatomical and biochemical features from P angulata that will assist in future phytochemistry and pharmacological studies, particularly pointing toward organs abundant in antioxidants (leaves and fruits) and steroids (possibly physalins; leaves).

10aAnatomy10aBotany10aElectron microscopy10aPhotochemistry10aPhysalis angulata1 aFerreira, Léa, Maria dos1 aVale, Ademir, Evangelist1 ade Souza, Amancio, José1 aLeite, Kelly, Batista1 aSacramento, Cássia1 aMoreno, Maria, Lucia Viei1 aAraújo, Thessika, Hialla1 aSoares, Milena, Botelho Pe1 aGrassi, Maria, Fernanda R uhttps://www.phcogres.com/article/2019/11/2/104103prpr9718