02676nas a2200265 4500008004100000245011900041210006900160260001800229300001200247490000700259520181200266653001902078653001602097653001802113653002102131653001602152653002602168100002902194700002602223700002102249700002302270700002502293700003002318856006202348 2018 eng d00aComparative Molluscicidal and Schistosomicidal Potentiality of Two Solanum Species and Its Isolated Glycoalkaloids0 aComparative Molluscicidal and Schistosomicidal Potentiality of T cFebruary 2018 a113-1170 v103 a

Schistosomiasis is the most noteworthy parasitic disease after malaria. Furthermore, the significant activity of the genus Solanum against Schistosoma worms and its intermediate host snails reinforced the study of Solanum seaforthianum Andr. (SS) and Solanum macrocarpon L. (SM) for their molluscicidal and schistosomicidal potentiality. In this study, different extracts, fractions and isolated compounds of both Solanum species are evaluated for the molluscicidal and schistosomicidal potentialities. The niclosamide was used as positive molluscicide control against Biomphalaria alexandrina snails. Different extracts, fractions, or isolated compounds were used at a concentration of 100 µg/ml and dead snails were counted in each case. On the other hand, washed and sterilized Schistosoma mansoni adult worms were used in three replicates, and three worm pairs were placed in each well with 2 ml test solution of 100 µg/ml concentration. Positive (praziquantel [PZQ] 0.2 ug/ml) and negative controls were concurrently used and examined daily for 3 days for viability. The mortality rate was calculated and then both LC50 and LC90 were determined in triplicates. Highest potency was indicated to total glycoalkaloid (TGA) fraction of SM followed by TGA of SS. On the other hand, TGA fractions of both species showed higher potency than other extracts and isolated compounds. Meanwhile, solasodine‑free aglycone showed declined activity compared to its glycosides. Promising molluscicidal and schistosomicidal activities were displayed which are attributed to the glycoalkaloid content. Therefore, this study can efficiently contribute toward validation of the traditional use of SS and SM in schistosomiasis control.

10aGlycoalkaloids10aMacrocarpon10aMolluscicidal10aSchistosomicidal10aSolamargine10aSolanum seaforthianum1 aAlsherbiny, Muhammad, A.1 aBadawy, Shymaa, A. El1 aElbedewy, Hesham1 aEzzat, Shahira, M.1 aElsakhawy, Fatma, S.1 aAbdel‑Kawy, Mostafa, A. uhttps://www.phcogres.com/article/2018/10/1/104103prpr7117